Dynamic modulation of autophagy: implications for aging and cancer.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Cassidy, Liam D https://orcid.org/0000-0002-9312-6256
Narita, Masashi https://orcid.org/0000-0001-7764-577X
Abstract
Reduced autophagy has been implicated in aging, yet whether its loss can promote aging phenotypes and pathologies in mammals, and how reversible this process is, has never been fully explored. Using inducible short hairpin RNA (shRNA) mouse models, we have recently shown that autophagy inhibition accelerates aging, and that even a temporary block in autophagy can create irreversible damage that increases a cancer risk.
Description
Keywords
Autophagy, aging, cancer, senescence
Journal Title
Mol Cell Oncol
Conference Name
Journal ISSN
2372-3556
2372-3556
2372-3556
Volume Title
7
Publisher
Informa UK Limited
Publisher DOI
Rights
All rights reserved
Sponsorship
Cancer Research UK (C9545/A29580_do not transfer)