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dc.contributor.authorBurton, Nicholas O
dc.contributor.authorRiccio, Cristian
dc.contributor.authorDallaire, Alexandra
dc.contributor.authorPrice, Jonathan
dc.contributor.authorJenkins, Benjamin
dc.contributor.authorKoulman, Albert
dc.contributor.authorMiska, Eric A
dc.date.accessioned2020-05-11T00:31:44Z
dc.date.available2020-05-11T00:31:44Z
dc.date.issued2020-04-08
dc.identifier.issn2041-1723
dc.identifier.otherPMC7142082
dc.identifier.other32269224
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305176
dc.description.abstractParental exposure to pathogens can prime offspring immunity in diverse organisms. The mechanisms by which this heritable priming occurs are largely unknown. Here we report that the soil bacteria Pseudomonas vranovensis is a natural pathogen of the nematode Caenorhabditis elegans and that parental exposure of animals to P. vranovensis promotes offspring resistance to infection. Furthermore, we demonstrate a multigenerational enhancement of progeny survival when three consecutive generations of animals are exposed to P. vranovensis. By investigating the mechanisms by which animals heritably adapt to P. vranovensis infection, we found that parental infection by P. vranovensis results in increased expression of the cysteine synthases cysl-1 and cysl-2 and the regulator of hypoxia inducible factor rhy-1 in progeny, and that these three genes are required for adaptation to P. vranovensis. These observations establish a CYSL-1, CYSL-2, and RHY-1 dependent mechanism by which animals heritably adapt to infection.
dc.languageeng
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceessn: 2041-1723
dc.sourcenlmid: 101528555
dc.titleCysteine synthases CYSL-1 and CYSL-2 mediate C. elegans heritable adaptation to P. vranovensis infection.
dc.typeArticle
dc.date.updated2020-05-11T00:31:44Z
prism.issueIdentifier1
prism.publicationNameNature communications
prism.volume11
dc.identifier.doi10.17863/CAM.52259
rioxxterms.versionofrecord10.1038/s41467-020-15555-8
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidBurton, Nicholas O [0000-0002-5495-3988]
dc.contributor.orcidDallaire, Alexandra [0000-0003-1097-7766]
dc.contributor.orcidPrice, Jonathan [0000-0001-6554-5667]
dc.contributor.orcidKoulman, Albert [0000-0001-9998-051X]
dc.contributor.orcidMiska, Eric A [0000-0002-4450-576X]
pubs.funder-project-idBiotechnology and Biological Sciences Research Council (BB/M027252/1)
pubs.funder-project-idCancer Research UK (C13474/A18583, C6946/A14492)
pubs.funder-project-idWellcome Trust (104640/Z/14/Z, 092096/Z/10/Z)


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International