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dc.contributor.authorSmith, Sam Sen
dc.contributor.authorStewart, Max Een
dc.contributor.authorDavies, Benen
dc.contributor.authorKotter, Marken
dc.date.accessioned2020-05-13T23:30:38Z
dc.date.available2020-05-13T23:30:38Z
dc.date.issued2021-05en
dc.identifier.issn2192-5682
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305369
dc.description.abstractStudy design: Systematic review and meta-analysis Objectives: Cervical spinal cord compression (SCC) due to degenerative changes of the spine is a frequent finding on MRI. Whilst most people remain asymptomatic, a proportion develop symptoms of degenerative cervical myelopathy (DCM). DCM is an often progressive neurological disease that can cause quadriplegia. The epidemiology of SCC and DCM is poorly understood. We sought to estimate the prevalence of degenerative cervical SCC and DCM from cross-sectional cohorts undergoing MRI. Methods: We conducted a systematic review and meta-analysis of MRI reports on human subjects over sixteen years of age with degenerative SCC. A pre-determined search strategy was used to identify relevant literature on MEDLINE. Title and abstract screening was followed by full text screening. Data was extracted and analysed by fixed or random effects-models. Results: The present search returned 1506 publications. Following our exclusion criteria, nineteen studies were included. Subgroup analysis of 3786 individuals estimated the prevalence of asymptomatic SCC in a healthy population as 24.2% with a significantly higher prevalence of SCC in older populations compared to younger populations and American/European populations compared to Asian populations. Subgroup analysis of 1202 individuals estimated the prevalence of DCM in a healthy population as 2.3%. Conclusions: We present the first estimates of the prevalence of asymptomatic SCC and DCM. Studies investigating the epidemiology of SCC are heterogeneous in methodology and results. These data indicate the need for more studies into the epidemiology of SCC and DCM performed with consistent methodologies.
dc.description.sponsorshipNIHR
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.rightsAll rights reserved
dc.rights.uri
dc.titleThe Prevalence of Asymptomatic and Symptomatic Spinal Cord Compression on Magnetic Resonance Imaging: A Systematic Review and Meta-analysis.en
dc.typeArticle
prism.endingPage607
prism.issueIdentifier4en
prism.publicationDate2021en
prism.publicationNameGlobal spine journalen
prism.startingPage597
prism.volume11en
dc.identifier.doi10.17863/CAM.52452
dcterms.dateAccepted2020-05-11en
rioxxterms.versionofrecord10.1177/2192568220934496en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-05en
dc.contributor.orcidSmith, Sam S [0000-0002-7654-9732]
dc.contributor.orcidDavies, Ben [0000-0003-0591-5069]
dc.contributor.orcidKotter, Mark [0000-0001-5145-7199]
dc.identifier.eissn2192-5690
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (CS-2015-15-023)
cam.orpheus.counter9*
rioxxterms.freetoread.startdate2023-05-13


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