Altered subcortical emotional salience processing differentiates Parkinson's patients with and without psychotic symptoms.
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Knolle, F., Garofalo, S., Viviani, R., Justicia, A., Ermakova, A., Blank, H., Williams, G., et al. (2020). Altered subcortical emotional salience processing differentiates Parkinson's patients with and without psychotic symptoms.. NeuroImage. Clinical, 27 102277. https://doi.org/10.1016/j.nicl.2020.102277
Objective: Current research does not provide a clear explanation for why some patients with Parkinson’s Disease (PD) develop psychotic symptoms. The ‘aberrant salience hypothesis’ of psychosis has been influential and proposes that dopaminergic dysregulation leads to inappropriate attribution of salience to irrelevant/non-informative stimuli, facilitating the formation of hallucinations and delusions. The aim of this study is to investigate whether non-motivational salience is altered in PD patients and possibly linked to the development of psychotic symptoms.
Brain, Amygdala, Humans, Parkinson Disease, Diagnosis, Differential, Magnetic Resonance Imaging, Emotions, Psychotic Disorders, Schizophrenia, Adult, Aged, Middle Aged, Female, Male
This study was supported by a MRC Clinician Scientist [G0701911] and an Isaac Newton Trust award to G.K.M., and by the Cambridge NIHR Biomedical Research Centre; and by the European Union’s Horizon 2020 to F.K. . T.W.R. discloses consultancy with Cambridge Cognition, Unilever and Greenfield Bioventures; he receives royalties from Cambridge Cognition, research grants from Shionogi & Co and GlaxoSmithKline, and editorial honoraria from Springer Nature and Elsevier. None of these conflict with the findings reported in this manuscript. None of the other authors report any conflicts of interest. R.A.B. discloses consultancy with Living Cell Technologies; Novo Nordisk; BlueRock 2 Therapeutics; Fujifilm Cellular Dynamics Inc; Aspen Neuroscience and UCB pharma and editorial honoraria from Springer Nature. None of these conflict with the findings reported in this manuscript.
Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) (unknown)
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External DOI: https://doi.org/10.1016/j.nicl.2020.102277
This record's URL: https://www.repository.cam.ac.uk/handle/1810/305372
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