Altered subcortical emotional salience processing differentiates Parkinson’s patients with and without psychotic symptoms

Knolle, Franziska; Justicia, A; Arrondo, G; Tudor-Sfetea, C; Barker, Roger; Murray, GK

Altered subcortical emotional salience processing differentiates Parkinson’s patients with and without psychotic symptoms

Published version

Peer-reviewed

Repository URI

https://www.repository.cam.ac.uk/handle/1810/305372

Repository DOI

https://doi.org/10.17863/CAM.52455

Files

Published version (1.37 MB)

Type

Article

Authors

Knolle, Franziska

Justicia, A

Arrondo, G

Tudor-Sfetea, C

Barker, Roger

https://orcid.org/0000-0001-8843-7730

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Abstract

Objective: Current research does not provide a clear explanation for why some patients with Parkinson’s Disease (PD) develop psychotic symptoms. The ‘aberrant salience hypothesis’ of psychosis has been influential and proposes that dopaminergic dysregulation leads to inappropriate attribution of salience to irrelevant/non-informative stimuli, facilitating the formation of hallucinations and delusions. The aim of this study is to investigate whether non-motivational salience is altered in PD patients and possibly linked to the development of psychotic symptoms.

Keywords

Adult, Aged, Amygdala, Brain, Diagnosis, Differential, Emotions, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease, Psychotic Disorders, Schizophrenia

Journal Title

NeuroImage: Clinical

Journal ISSN

2213-1582
2213-1582

Volume Title

27

Publisher

Elsevier

Publisher DOI

https://doi.org/10.1016/j.nicl.2020.102277

Rights

Attribution 4.0 International

Sponsorship

Medical Research Council (G0701911)
Cambridgeshire and Peterborough NHS Foundation Trust (CPFT) (unknown)
Medical Research Council (G0701911/1)

This study was supported by a MRC Clinician Scientist [G0701911] and an Isaac Newton Trust award to G.K.M., and by the Cambridge NIHR Biomedical Research Centre; and by the European Union’s Horizon 2020 to F.K. [754462]. T.W.R. discloses consultancy with Cambridge Cognition, Unilever and Greenfield Bioventures; he receives royalties from Cambridge Cognition, research grants from Shionogi & Co and GlaxoSmithKline, and editorial honoraria from Springer Nature and Elsevier. None of these conflict with the findings reported in this manuscript. None of the other authors report any conflicts of interest. R.A.B. discloses consultancy with Living Cell Technologies; Novo Nordisk; BlueRock 2 Therapeutics; Fujifilm Cellular Dynamics Inc; Aspen Neuroscience and UCB pharma and editorial honoraria from Springer Nature. None of these conflict with the findings reported in this manuscript.

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Is derived from:

https://doi.org/10.1101/19010512

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Cambridge University Research Outputs