In vitro-derived platelets: the challenges we will have to face to assess quality and safety.
Taylor & Francis
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Mookerjee, S., Foster, H., Waller, A., & Ghevaert, C. (2020). In vitro-derived platelets: the challenges we will have to face to assess quality and safety.. Platelets, 31 (6), 724-730. https://doi.org/10.1080/09537104.2020.1769051
Platelet transfusions are given to patients in hospital who have a low blood platelet count (thrombocytopenia) either because of major bleeding (following trauma or surgery) or because the bone marrow production of platelets is impaired often due to chemotherapy, infiltration with malignant cells, fibrosis or genetic disorders. We are currently entirely reliant on blood donors as a source of platelets in transfusion medicine. However, the demand for platelets continues to rise, driven by an ageing population, advances in medical procedures and ever more aggressive cancer therapies, while the supply of blood donors continues to remain static.
Blood Platelets, Humans, Cell Culture Techniques
This work was supported by grants from the Rosetrees Trust (A1691), NHS Blood and Transplant and the European Union (SilkFusion: AMD-767309-3).
Rosetrees Trust (A1691)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (767309)
Medical Research Council (MC_PC_17230)
External DOI: https://doi.org/10.1080/09537104.2020.1769051
This record's URL: https://www.repository.cam.ac.uk/handle/1810/305377
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