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dc.contributor.authorPalacio-Torralba, Javier
dc.contributor.authorJiménez Aguilar, Elizabeth
dc.contributor.authorGood, Daniel W
dc.contributor.authorHammer, Steven
dc.contributor.authorMcNeill, S Alan
dc.contributor.authorStewart, Grant D
dc.contributor.authorReuben, Robert L
dc.contributor.authorChen, Yuhang
dc.date.accessioned2020-05-14T23:30:14Z
dc.date.available2020-05-14T23:30:14Z
dc.date.issued2016-01
dc.identifier.issn2040-7939
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305416
dc.description.abstractComputational modeling has become a successful tool for scientific advances including understanding the behavior of biological and biomedical systems as well as improving clinical practice. In most cases, only general models are used without taking into account patient-specific features. However, patient specificity has proven to be crucial in guiding clinical practice because of disastrous consequences that can arise should the model be inaccurate. This paper proposes a framework for the computational modeling applied to the example of the male pelvic cavity for the purpose of prostate cancer diagnostics using palpation. The effects of patient specific structural features on palpation response are studied in three selected patients with very different pathophysiological conditions whose pelvic cavities are reconstructed from MRI scans. In particular, the role of intrabladder pressure in the outcome of digital rectal examination is investigated with the objective of providing guidelines to practitioners to enhance the effectiveness of diagnosis. Furthermore, the presence of the pelvic bone in the model is assessed to determine the pathophysiological conditions in which it has to be modeled. The conclusions and suggestions of this work have potential use not only in clinical practice and also for biomechanical modeling where structural patient-specificity needs to be considered. © 2015 The Authors. International Journal for Numerical Methods in Biomedical Engineering published by John Wiley & Sons Ltd.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectPelvis
dc.subjectHumans
dc.subjectProstatic Neoplasms
dc.subjectDiagnosis, Computer-Assisted
dc.subjectPalpation
dc.subjectSensitivity and Specificity
dc.subjectReproducibility of Results
dc.subjectManometry
dc.subjectPressure
dc.subjectModels, Biological
dc.subjectComputer Simulation
dc.subjectMale
dc.subjectUrinary Bladder
dc.titlePatient specific modeling of palpation-based prostate cancer diagnosis: effects of pelvic cavity anatomy and intrabladder pressure.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2016
prism.publicationNameInt J Numer Method Biomed Eng
prism.startingPagee02734
prism.volume32
dc.identifier.doi10.17863/CAM.52496
dcterms.dateAccepted2015-06-08
rioxxterms.versionofrecord10.1002/cnm.2734
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-01
dc.contributor.orcidStewart, Grant [0000-0003-3188-9140]
dc.identifier.eissn2040-7947
rioxxterms.typeJournal Article/Review
cam.issuedOnline2015-08-19


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International