Transglutaminase 3 Reduces the Severity of Psoriasis in Imiquimod-Treated Mouse Skin.
Published version
Peer-reviewed
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Repository DOI
Change log
Authors
Piro, Maria Cristina
Ventura, Alessandra
Smirnov, Artem
Saggini, Andrea
Lena, Anna Maria
Abstract
Four transglutaminase (TG) isoforms have been detected in epidermal keratinocytes: TG1, TG2, TG3, and TG5. Except for TG1 and TG3, their contribution to keratinocyte development and structure remains undefined. In this paper, we focused on the roles of TG2 and TG3 in imiquimod-induced psoriasis in mouse skin. We evaluated the severity of psoriasis markers in the skin of imiquimod-treated TG3 null and TG2 null mice. Our results showed that compromised TG3KO mouse skin was more responsive than WT or TG2KO mouse skin to the action of the pro-inflammatory drug imiquimod.
Description
Keywords
TG2KO, TG3KO, imiquimod, inflammation, psoriasis, skin, transglutaminase 2, transglutaminase 3, Animals, GTP-Binding Proteins, Imiquimod, Keratinocytes, Male, Mice, Mice, Inbred C57BL, Protein Glutamine gamma Glutamyltransferase 2, Psoriasis, Transglutaminases
Journal Title
Int J Mol Sci
Conference Name
Journal ISSN
1661-6596
1422-0067
1422-0067
Volume Title
21
Publisher
MDPI AG