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Placental imprinting: Emerging mechanisms and functions.

Published version
Peer-reviewed

Type

Article

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Authors

Abstract

As the maternal-foetal interface, the placenta is essential for the establishment and progression of healthy pregnancy, regulating both foetal growth and maternal adaptation to pregnancy. The evolution and functional importance of genomic imprinting are inextricably linked to mammalian placentation. Recent technological advances in mapping and manipulating the epigenome in embryogenesis in mouse models have revealed novel mechanisms regulating genomic imprinting in placental trophoblast, the physiological implications of which are only just beginning to be explored. This review will highlight important recent discoveries and exciting new directions in the study of placental imprinting.

Description

Keywords

Animals, DNA Methylation, Female, Genomic Imprinting, Humans, Placenta, Pregnancy, Retroelements

Journal Title

PLoS Genet

Conference Name

Journal ISSN

1553-7390
1553-7404

Volume Title

16

Publisher

Public Library of Science (PLoS)
Sponsorship
Next Generation Fellowship from the Centre for Trophoblast Research