Show simple item record

dc.contributor.authorHill, Ciaran S.
dc.contributor.authorSreedharan, Jemeen
dc.contributor.authorLoreto, Andrea
dc.contributor.authorMenon, David K.
dc.contributor.authorColeman, Michael P.
dc.date.accessioned2020-05-26T06:13:59Z
dc.date.available2020-05-26T06:13:59Z
dc.date.issued2020-05-12
dc.date.submitted2020-01-10
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305739
dc.description.abstractTraumatic brain injury is a major global cause of death and disability. Axonal injury is a major underlying mechanism of TBI and could represent a major therapeutic target. We provide evidence that targeting the axonal death pathway known as Wallerian degeneration improves outcome in a Drosophila Melanogaster model of high impact trauma. This cell-autonomous neurodegenerative pathway is initiated following axon injury, and in Drosophila, involves activity of the E3 ubiquitin ligase highwire. We demonstrate that a loss-of-function mutation in the highwire gene rescues deleterious effects of a traumatic injury, including—improved functional outcomes, lifespan, survival of dopaminergic neurons, and retention of synaptic proteins. This data suggests that highwire represents a potential therapeutic target in traumatic injury.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectNeurology
dc.subjectwallerian degeneration
dc.subjecttraumatic brain injury
dc.subjectneuroprotection
dc.subjectaxons
dc.subjecthighwire
dc.titleLoss of highwire Protects Against the Deleterious Effects of Traumatic Brain Injury in Drosophila Melanogaster
dc.typeOther
dc.date.updated2020-05-26T06:13:58Z
prism.publicationNameFrontiers in Neurology
prism.volume11
dc.identifier.doi10.17863/CAM.52817
dcterms.dateAccepted2020-04-17
rioxxterms.versionofrecord10.3389/fneur.2020.00401
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn1664-2295


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)