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Evaluating the Effect of Non-cellular Bioactive Glass-Containing Scaffolds on Osteogenesis and Angiogenesis in in vivo Animal Bone Defect Models

Published version
Peer-reviewed

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Authors

Ranmuthu, Chanuka D. S. 
Ranmuthu, Charindu K. I. 
Russell, Jodie C. 
Singhania, Disha 
Khan, Wasim S. 

Abstract

The use of bone scaffolds to replace injured or diseased bone has many advantages over the currently used autologous and allogeneic options in clinical practice. This systematic review evaluates the current evidence for non-cellular scaffolds containing bioactive glass on osteogenesis and angiogenesis in animal bone defect models. Studies that reported results of osteogenesis via micro-CT and results of angiogenesis via Microfil perfusion or immunohistochemistry were included in the review. A literature search of PubMed, EMBASE and Scopus was carried out in November 2019 from which nine studies met the inclusion and exclusion criteria. Despite the significant heterogeneity in the composition of the scaffolds used in each study, it could be concluded that scaffolds containing bioactive glass improve bone regeneration in these models, both by osteogenic and angiogenic measures. Incorporation of additional elements into the glass network, using additives, and using biochemical factors generally had a beneficial effect. Comparing the different compositions of non-cellular bioactive glass containing scaffolds is however difficult due to the heterogeneity in bioactive glass compositions, fabrication methods and biochemical additives used.

Description

Keywords

Bioengineering and Biotechnology, scaffolds, bone, bioactive glass, osteogenesis, angiogenesis

Journal Title

Frontiers in Bioengineering and Biotechnology

Conference Name

Journal ISSN

2296-4185

Volume Title

8

Publisher

Frontiers Media S.A.