Show simple item record

dc.contributor.authorRanmuthu, Chanuka D. S.
dc.contributor.authorRanmuthu, Charindu K. I.
dc.contributor.authorRussell, Jodie C.
dc.contributor.authorSinghania, Disha
dc.contributor.authorKhan, Wasim S.
dc.date.accessioned2020-05-28T05:11:43Z
dc.date.available2020-05-28T05:11:43Z
dc.date.issued2020-05-14
dc.date.submitted2019-12-09
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305837
dc.description.abstractThe use of bone scaffolds to replace injured or diseased bone has many advantages over the currently used autologous and allogeneic options in clinical practice. This systematic review evaluates the current evidence for non-cellular scaffolds containing bioactive glass on osteogenesis and angiogenesis in animal bone defect models. Studies that reported results of osteogenesis via micro-CT and results of angiogenesis via Microfil perfusion or immunohistochemistry were included in the review. A literature search of PubMed, EMBASE and Scopus was carried out in November 2019 from which nine studies met the inclusion and exclusion criteria. Despite the significant heterogeneity in the composition of the scaffolds used in each study, it could be concluded that scaffolds containing bioactive glass improve bone regeneration in these models, both by osteogenic and angiogenic measures. Incorporation of additional elements into the glass network, using additives, and using biochemical factors generally had a beneficial effect. Comparing the different compositions of non-cellular bioactive glass containing scaffolds is however difficult due to the heterogeneity in bioactive glass compositions, fabrication methods and biochemical additives used.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectBioengineering and Biotechnology
dc.subjectscaffolds
dc.subjectbone
dc.subjectbioactive glass
dc.subjectosteogenesis
dc.subjectangiogenesis
dc.titleEvaluating the Effect of Non-cellular Bioactive Glass-Containing Scaffolds on Osteogenesis and Angiogenesis in in vivo Animal Bone Defect Models
dc.typeArticle
dc.date.updated2020-05-28T05:11:42Z
prism.publicationNameFrontiers in Bioengineering and Biotechnology
prism.volume8
dc.identifier.doi10.17863/CAM.52917
dcterms.dateAccepted2020-04-15
rioxxterms.versionofrecord10.3389/fbioe.2020.00430
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2296-4185


Files in this item

Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)