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dc.contributor.authorSundar, Raghav
dc.contributor.authorSmyth, Elizabeth C.
dc.contributor.authorPeng, Siyu
dc.contributor.authorYeong, Joe P. S.
dc.contributor.authorTan, Patrick
dc.date.accessioned2020-05-29T15:05:57Z
dc.date.available2020-05-29T15:05:57Z
dc.date.issued2020-05-15
dc.date.submitted2020-01-17
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/305880
dc.description.abstractImmune checkpoint inhibition has transformed cancer treatment. For gastroesophageal cancer, this class of drugs have demonstrated durable responses and survival benefit in a subgroup of patients, resulting in regulatory approval. However, several recent randomized phase III studies in gastroesophageal cancer have reported negative results, blunting initial enthusiasm. Identification and validation of predictive biomarkers with appropriate patient selection for benefit from immunotherapy is an area of intense research with novel concepts rapidly emerging. In this review we describe the latest immune checkpoint inhibitor trials which have been reported in gastroesophageal cancers with a focus on predictive biomarkers. We also explore novel biomarkers being developed to improve precision oncology for immunotherapy in gastroesophageal cancers.
dc.languageen
dc.publisherFrontiers Media S.A.
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectOncology
dc.subjectimmunotherapy
dc.subjectbiomarker
dc.subjectgastric cancer
dc.subjectesophageal cancer
dc.subjectgastroesophageal cancer
dc.subjectimmune checkpoint inhibition
dc.subjectpredictive biomarker
dc.subjectprecision oncology
dc.titlePredictive Biomarkers of Immune Checkpoint Inhibition in Gastroesophageal Cancers
dc.typeArticle
dc.date.updated2020-05-29T15:05:57Z
prism.publicationNameFrontiers in Oncology
prism.volume10
dc.identifier.doi10.17863/CAM.52961
dcterms.dateAccepted2020-04-21
rioxxterms.versionofrecord10.3389/fonc.2020.00763
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
dc.identifier.eissn2234-943X


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)