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Deadly encounter: Endosomes meet Mitochondria to initiate Apoptosis

Accepted version
Peer-reviewed

Type

Article

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Authors

Vicinanza, Mariella 

Abstract

Mitochondrial outer membrane permeabilization (MOMP) is a crucial event enabling apoptotic cell death. In this issue of Developmental Cell, Wang et al. reveal an interaction contributing to full MOMP execution, which depends on endosomes accumulating on apoptotic mitochondria. This causes mitochondrial lipid alterations that may contribute to functional pore assembly.

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Keywords

Journal Title

Developmental Cell

Conference Name

Journal ISSN

1534-5807

Volume Title

Publisher

Elsevier