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dc.contributor.authorTay, Jonathan
dc.contributor.authorMorris, Robin G
dc.contributor.authorTuladhar, Anil M
dc.contributor.authorHusain, Masud
dc.contributor.authorde Leeuw, Frank-Erik
dc.contributor.authorMarkus, Hugh S
dc.date.accessioned2020-06-03T23:30:33Z
dc.date.available2020-06-03T23:30:33Z
dc.date.issued2020-09
dc.identifier.issn0022-3050
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/306096
dc.description.abstractOBJECTIVE: To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. METHODS: Analyses used two prospective cohort studies of SVD: St. George's Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using baseline apathy and depression scores in both datasets. Change in apathy and depression was used to predict dementia in a subset of 104 participants with longitudinal data from SCANS. All models were controlled for age, education and cognitive function. RESULTS: Baseline apathy scores predicted dementia in SCANS (HR 1.49, 95% CI 1.05 to 2.11, p=0.024) and RUN DMC (HR 1.05, 95% CI 1.01 to 1.09, p=0.007). Increasing apathy was associated with dementia in SCANS (HR 1.53, 95% CI 1.08 to 2.17, p=0.017). In contrast, baseline depression and change in depression did not predict dementia in either dataset. Including apathy in predictive models of dementia improved model fit. CONCLUSIONS: Apathy, but not depression, may be a prodromal symptom of dementia in SVD, and may be useful in identifying at-risk individuals.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherBMJ
dc.rightsAll rights reserved
dc.subjectHumans
dc.subjectDementia
dc.subjectProspective Studies
dc.subjectPredictive Value of Tests
dc.subjectDepression
dc.subjectAged
dc.subjectFemale
dc.subjectMale
dc.subjectApathy
dc.subjectCerebral Small Vessel Diseases
dc.subjectProdromal Symptoms
dc.titleApathy, but not depression, predicts all-cause dementia in cerebral small vessel disease.
dc.typeArticle
prism.endingPage959
prism.issueIdentifier9
prism.publicationDate2020
prism.publicationNameJ Neurol Neurosurg Psychiatry
prism.startingPage953
prism.volume91
dc.identifier.doi10.17863/CAM.53175
dcterms.dateAccepted2020-06-02
rioxxterms.versionofrecord10.1136/jnnp-2020-323092
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-09
dc.contributor.orcidTay, Jonathan [0000-0003-0598-0004]
dc.contributor.orcidTuladhar, Anil M [0000-0002-4815-2834]
dc.identifier.eissn1468-330X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idStroke Association (PPA 2015/02)
cam.issuedOnline2020-07-10
cam.orpheus.successMon Jul 20 07:54:23 BST 2020 - Embargo updated
cam.orpheus.counter7
rioxxterms.freetoread.startdate2020-07-10


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