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dc.contributor.authorTay, Jonathanen
dc.contributor.authorMorris, Robin Gen
dc.contributor.authorTuladhar, Anil Men
dc.contributor.authorHusain, Masuden
dc.contributor.authorde Leeuw, Frank-Eriken
dc.contributor.authorMarkus, Hughen
dc.date.accessioned2020-06-03T23:30:33Z
dc.date.available2020-06-03T23:30:33Z
dc.date.issued2020-09en
dc.identifier.issn0022-3050
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/306096
dc.description.abstractObjective: To determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients. Methods: Analyses used two prospective cohort studies of SVD: St. George's Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion tensor and Magnetic resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using baseline apathy and depression scores in both datasets. Change in apathy and depression was used to predict dementia in a subset of 104 participants with longitudinal data from SCANS. All models were controlled for age, education, and cognitive function. Results: Baseline apathy scores predicted dementia in SCANS (HR=1.49, 95% CI=1.05-2.11, P=0.024), and RUN DMC (HR=1.05, 95% CI=1.01-1.09, P=0.007). Increasing apathy was associated with dementia in SCANS (HR=1.53, 95% CI=1.08-2.17, P=0.017). In contrast, baseline depression and change in depression did not predict dementia in either dataset. Including apathy in predictive models of dementia improved model fit. Conclusions: Apathy, but not depression, may be a prodromal symptom of dementia in SVD, and may be useful in identifying at-risk individuals.
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherBMJ
dc.rightsAll rights reserved
dc.rights.uri
dc.subjectHumansen
dc.subjectDementiaen
dc.subjectProspective Studiesen
dc.subjectPredictive Value of Testsen
dc.subjectDepressionen
dc.subjectAgeden
dc.subjectFemaleen
dc.subjectMaleen
dc.subjectApathyen
dc.subjectCerebral Small Vessel Diseasesen
dc.subjectProdromal Symptomsen
dc.titleApathy, but not depression, predicts all-cause dementia in cerebral small vessel disease.en
dc.typeArticle
prism.endingPage959
prism.issueIdentifier9en
prism.publicationDate2020en
prism.publicationNameJournal of neurology, neurosurgery, and psychiatryen
prism.startingPage953
prism.volume91en
dc.identifier.doi10.17863/CAM.53175
dcterms.dateAccepted2020-06-02en
rioxxterms.versionofrecord10.1136/jnnp-2020-323092en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-09en
dc.contributor.orcidTay, Jonathan [0000-0003-0598-0004]
dc.contributor.orcidTuladhar, Anil M [0000-0002-4815-2834]
dc.contributor.orcidMarkus, Hugh [0000-0002-9794-5996]
dc.identifier.eissn1468-330X
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idStroke Association (PPA 2015/02)
cam.orpheus.successMon Jul 20 07:54:23 BST 2020 - Embargo updated*
cam.orpheus.counter7*
rioxxterms.freetoread.startdate2020-07-10


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