Synergism of anisotropic and computational NMR methods reveals the likely configuration of phormidolide A.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Ndukwe, Ikenna E https://orcid.org/0000-0003-2412-6970
Wang, Xiao
Lam, Nelson YS https://orcid.org/0000-0002-9307-0619
Ermanis, Kristaps
Alexander, Kelsey L https://orcid.org/0000-0002-4727-5349
Abstract
Characterization of the complex molecular scaffold of the marine polyketide natural product phormidolide A represents a challenge that has persisted for nearly two decades. In light of discordant results arising from recent synthetic and biosynthetic reports, a rigorous study of the configuration of phormidolide A was necessary. This report outlines a synergistic effort employing computational and anisotropic NMR investigation, that provided orthogonal confirmation of the reassigned side chain, as well as supporting a further correction of the C7 stereocenter.
Description
Keywords
Anisotropy, Macrolides, Magnetic Resonance Spectroscopy, Molecular Conformation, Stereoisomerism
Journal Title
Chem Commun (Camb)
Conference Name
Journal ISSN
1359-7345
1364-548X
1364-548X
Volume Title
56
Publisher
Royal Society of Chemistry (RSC)
Publisher DOI
Rights
All rights reserved
Sponsorship
Isaac Newton Trust (17.08(D))
Leverhulme Trust (ECF-2017-255)
Leverhulme Trust (ECF-2017-255)