Separating vascular and neuronal effects of age on fMRI BOLD signals.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
The Royal Society
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Tsvetanov, K. A., Henson, R., & Rowe, J. (2021). Separating vascular and neuronal effects of age on fMRI BOLD signals.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 376 (1815), 20190631. https://doi.org/10.1098/rstb.2019.0631
Accurate identification of brain function is necessary to understand the neurobiology of cognitive ageing, and thereby promote well-being across the lifespan. A common tool used to investigate neurocognitive ageing is functional magnetic resonance imaging (fMRI). However, although fMRI data are often interpreted in terms of neuronal activity, the blood-oxygen-level-dependent (BOLD) signal measured by fMRI includes contributions of both vascular and neuronal factors, which change differentially with age. While some studies investigate vascular ageing factors, the results of these studies are not well known within the field of neurocognitive ageing and therefore vascular confounds in neurocognitive fMRI studies are common. Despite over 10,000 BOLD-fMRI papers on ageing, fewer than 20 have applied techniques to correct for vascular effects. However, neurovascular ageing is not only a confound in fMRI, but an important feature in its own right, to be assessed alongside measures of neuronal ageing. We review current approaches to dissociate neuronal and vascular components of BOLD-fMRI of regional activity and functional connectivity. We highlight emerging evidence that vascular mechanisms in the brain do not simply control blood flow to support the metabolic needs of neurons, but form complex neurovascular interactions that influence neuronal function in health and disease.
This work is supported by the British Academy (PF160048), the Guarantors of Brain (G101149), the Wellcome Trust (103838), the Medical Research Council (SUAG/051 G101400; and SUAG/046 G101400), European Union’s Horizon 2020 (732592) and the Cambridge NIHR Biomedical Research Centre.
British Academy (pf160048)
Guarantors of Brain (Unknown)
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External DOI: https://doi.org/10.1098/rstb.2019.0631
This record's URL: https://www.repository.cam.ac.uk/handle/1810/306685
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