Helminths, hosts, and their microbiota: new avenues for managing gastrointestinal helminthiases in ruminants.
Bartley, Dave J
Nisbet, Alasdair J
Expert review of anti-infective therapy
Taylor & Francis
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Cortés, A., Rooney, J., Bartley, D. J., Nisbet, A. J., & Cantacessi, C. (2020). Helminths, hosts, and their microbiota: new avenues for managing gastrointestinal helminthiases in ruminants.. Expert review of anti-infective therapy, 18 (10), 977-985. https://doi.org/10.1080/14787210.2020.1782188
Introduction Evidence is emerging of complex interactions occurring between gastrointestinal (GI) parasites of ruminants and the resident gut flora, with likely implications for the pathophysiology of worm infection and disease. Similarly, recent data point towards the occurrence of a GI nematode (GIN)-specific microbiota, with potential roles in worm fundamental physiology and reproduction. Overall, parasite-microbiota relationships might represent potential targets for the development of novel parasiticides. Areas covered In this article, we review current knowledge of the role(s) that host- and helminth-associated microbiota play in ruminant host-parasite relationships, and outline potential avenues for the control of GIN of farmed ruminants via the manipulation of microbial species with putative functions in infection establishment, host-immune modulation and/or parasite fitness and survival. Expert opinion/commentary In order for this knowledge to be translated into practical applications, we argue that several aspects of the nematode-microbiota cross-talk must be addressed, including (i) the causality of interactions between the parasite, gut microbiota and immune system, (ii) the modes of action of dietary prebiotics and probiotics, (iii) the mechanisms by which diet supplementation aids the development of resistance/tolerance to GI helminth infections and (iv) the composition of the GIN microbiome and its role(s) in parasite biology and physiology.
Animals, Ruminants, Helminths, Helminthiasis, Animal, Anthelmintics, Probiotics, Host-Parasite Interactions, Prebiotics, Gastrointestinal Microbiome, Drug Development
Isaac Newton Trust (Minute 17.37(q))
External DOI: https://doi.org/10.1080/14787210.2020.1782188
This record's URL: https://www.repository.cam.ac.uk/handle/1810/306717
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