Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments.
Published version
Peer-reviewed
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Repository DOI
Type
Article
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Authors
Masson, Glenn R https://orcid.org/0000-0002-1386-4719
Burke, John E https://orcid.org/0000-0001-7904-9859
Ahn, Natalie G
Anand, Ganesh S
Borchers, Christoph
Abstract
Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful biophysical technique being increasingly applied to a wide variety of problems. As the HDX-MS community continues to grow, adoption of best practices in data collection, analysis, presentation and interpretation will greatly enhance the accessibility of this technique to nonspecialists. Here we provide recommendations arising from community discussions emerging out of the first International Conference on Hydrogen-Exchange Mass Spectrometry (IC-HDX; 2017). It is meant to represent both a consensus viewpoint and an opportunity to stimulate further additions and refinements as the field advances.
Description
Keywords
Data Analysis, Deuterium Exchange Measurement, Hydrogen-Ion Concentration, Mass Spectrometry
Journal Title
Nat Methods
Conference Name
Journal ISSN
1548-7091
1548-7105
1548-7105
Volume Title
16
Publisher
Springer Science and Business Media LLC