Of Cell Shapes and Motion: The Physical Basis of Animal Cell Migration.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Bodor, Dani L
Pönisch, Wolfram
Endres, Robert G
Paluch, Ewa K
Abstract
Motile cells have developed a variety of migration modes relying on diverse traction-force-generation mechanisms. Before the behavior of intracellular components could be easily imaged, cell movements were mostly classified by different types of cellular shape dynamics. Indeed, even though some types of cells move without any significant change in shape, most cell propulsion mechanisms rely on global or local deformations of the cell surface. In this review, focusing mostly on metazoan cells, we discuss how different types of local and global shape changes underlie distinct migration modes. We then discuss mechanical differences between force-generation mechanisms and finish by speculating on how they may have evolved.
Description
Keywords
Animals, Cell Movement, Cell Shape, Mechanical Phenomena, Pseudopodia
Journal Title
Dev Cell
Conference Name
Journal ISSN
1534-5807
1878-1551
1878-1551
Volume Title
52
Publisher
Elsevier BV
Publisher DOI
Sponsorship
European Research Council (820188)
Medical Research Council (MC_UU_00012/5)
Medical Research Council (MC_UU_00012/5)