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Of Cell Shapes and Motion: The Physical Basis of Animal Cell Migration.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Bodor, Dani L 
Pönisch, Wolfram 
Endres, Robert G 
Paluch, Ewa K 

Abstract

Motile cells have developed a variety of migration modes relying on diverse traction-force-generation mechanisms. Before the behavior of intracellular components could be easily imaged, cell movements were mostly classified by different types of cellular shape dynamics. Indeed, even though some types of cells move without any significant change in shape, most cell propulsion mechanisms rely on global or local deformations of the cell surface. In this review, focusing mostly on metazoan cells, we discuss how different types of local and global shape changes underlie distinct migration modes. We then discuss mechanical differences between force-generation mechanisms and finish by speculating on how they may have evolved.

Description

Keywords

Animals, Cell Movement, Cell Shape, Mechanical Phenomena, Pseudopodia

Journal Title

Dev Cell

Conference Name

Journal ISSN

1534-5807
1878-1551

Volume Title

52

Publisher

Elsevier BV
Sponsorship
European Research Council (820188)
Medical Research Council (MC_UU_00012/5)