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dc.contributor.authorPaluch, Ewa K
dc.contributor.authorAspalter, Irene M
dc.contributor.authorSixt, Michael
dc.date.accessioned2020-07-02T23:30:55Z
dc.date.available2020-07-02T23:30:55Z
dc.date.issued2016-10-06
dc.identifier.issn1081-0706
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/307534
dc.description.abstractCell migration is central to a multitude of physiological processes, including embryonic development, immune surveillance, and wound healing, and deregulated migration is key to cancer dissemination. Decades of investigations have uncovered many of the molecular and physical mechanisms underlying cell migration. Together with protrusion extension and cell body retraction, adhesion to the substrate via specific focal adhesion points has long been considered an essential step in cell migration. Although this is true for cells moving on two-dimensional substrates, recent studies have demonstrated that focal adhesions are not required for cells moving in three dimensions, in which confinement is sufficient to maintain a cell in contact with its substrate. Here, we review the investigations that have led to challenging the requirement of specific adhesions for migration, discuss the physical mechanisms proposed for cell body translocation during focal adhesion-independent migration, and highlight the remaining open questions for the future.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherAnnual Reviews
dc.rightsAll rights reserved
dc.subjectFocal Adhesions
dc.subjectAnimals
dc.subjectHumans
dc.subjectCell Movement
dc.subjectModels, Biological
dc.subjectBiomechanical Phenomena
dc.titleFocal Adhesion-Independent Cell Migration.
dc.typeArticle
prism.endingPage490
prism.publicationDate2016
prism.publicationNameAnnu Rev Cell Dev Biol
prism.startingPage469
prism.volume32
dc.identifier.doi10.17863/CAM.54624
rioxxterms.versionofrecord10.1146/annurev-cellbio-111315-125341
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2016-10
dc.contributor.orcidPaluch, Ewa Kamila [0000-0003-4691-2323]
dc.identifier.eissn1530-8995
rioxxterms.typeJournal Article/Review
cam.issuedOnline2016-08-04
rioxxterms.freetoread.startdate2017-10-31


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