Show simple item record

dc.contributor.authorWagner, Adam P
dc.contributor.authorCarroll, Cliodhna
dc.contributor.authorWhite, Simon
dc.contributor.authorWatson, Peter
dc.contributor.authorSpoudeas, Helen A
dc.contributor.authorHawkins, Michael M
dc.contributor.authorWalker, David A
dc.contributor.authorClare, Isabel
dc.contributor.authorHolland, Anthony
dc.contributor.authorRing, Howard
dc.date.accessioned2020-07-03T23:30:36Z
dc.date.available2020-07-03T23:30:36Z
dc.date.issued2020-10
dc.identifier.issn1341-9625
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/307597
dc.description.abstractPURPOSE: Posterior fossa brain tumours (PFT) and their treatment in young children are often associated with subsequent cognitive impairment. However, reported follow-up periods rarely exceed 10 years. This study reports very long-term cognitive consequences of surviving an early childhood PFT. METHODS: 62 adult survivors of a PFT, ascertained from a national register, diagnosed before 5 years of age, and a sibling control, received a single IQ assessment an average of 32 years (range 18-53) after initial diagnosis, using the Weschler Abbreviated Scale of Intelligence. Regression models were fitted to survivor-sibling pair differences on verbal and performance IQ (VIQ and PIQ) scores to investigate whether increasing time between PFT diagnosis and follow-up IQ assessment contributed to survivor-sibling IQ differences. RESULTS: At follow-up, survivors had, on average, VIQ 15 points and PIQ 19 points lower than their siblings. There was no significant effect of time since diagnosis on survivor-sibling VIQ difference. Survivors who received radiotherapy showed no significant effect of time since diagnosis on survivor-sibling PIQ difference. Survivors who did not receive radiotherapy demonstrated a trend for it to reduce. CONCLUSIONS: VIQ and PIQ deficits persist in adulthood, suggesting the effect of a fixed injury imposing on cognitive development, rather than an ongoing pathological process. IMPLICATIONS FOR CANCER SURVIVORS: The findings will help parents and others supporting survivors of an early life PFT to identify and plan for possible cognitive outcomes, and highlight the importance of early interventions to optimize cognitive function during the developmental period.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll rights reserved
dc.subjectHumans
dc.subjectBrain Neoplasms
dc.subjectLongitudinal Studies
dc.subjectSiblings
dc.subjectCognition
dc.subjectIntelligence Tests
dc.subjectAdolescent
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectChild, Preschool
dc.subjectFemale
dc.subjectMale
dc.subjectYoung Adult
dc.subjectCancer Survivors
dc.titleLong-term cognitive outcome in adult survivors of an early childhood posterior fossa brain tumour.
dc.typeArticle
prism.endingPage1773
prism.issueIdentifier10
prism.publicationDate2020
prism.publicationNameInt J Clin Oncol
prism.startingPage1763
prism.volume25
dc.identifier.doi10.17863/CAM.54686
dcterms.dateAccepted2020-06-11
rioxxterms.versionofrecord10.1007/s10147-020-01725-7
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-10
dc.contributor.orcidWagner, Adam P [0000-0002-9101-3477]
dc.contributor.orcidWhite, Simon [0000-0001-8642-7037]
dc.contributor.orcidWatson, Peter [0000-0002-9436-0693]
dc.contributor.orcidClare, Isabel [0000-0002-5385-008X]
dc.contributor.orcidHolland, Anthony [0000-0003-4107-130X]
dc.contributor.orcidRing, Howard [0000-0001-6213-781X]
dc.identifier.eissn1437-7772
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMRC (1185)
pubs.funder-project-idMedical Research Council (MC_UU_00005/14)
pubs.funder-project-idMRC (unknown)
cam.issuedOnline2020-07-08
cam.orpheus.successMon Jul 13 08:26:53 BST 2020 - Embargo updated
cam.orpheus.counter1
rioxxterms.freetoread.startdate2021-07-08


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record