Probabilistic reversal learning under acute tryptophan depletion in healthy humans: a conventional analysis.
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Kanen, Jonathan W. https://orcid.org/0000-0002-4095-5405
Arntz, Frederique E
Yellowlees, Robyn
Cardinal, Rudolf N
Price, Annabel https://orcid.org/0000-0002-5505-5231
Abstract
The involvement of serotonin in responses to negative feedback is well established. Acute serotonin reuptake inhibition has enhanced sensitivity to negative feedback (SNF), modelled by behaviour in probabilistic reversal learning (PRL) paradigms. Whilst experiments employing acute tryptophan depletion (ATD) in humans, to reduce serotonin synthesis, have shown no clear effect on SNF, sample sizes have been small. We studied a large sample of healthy volunteers, male and female, and found ATD had no effect on core behavioural measures in PRL. These results indicate that ATD effects can differ from other manipulations of serotonin expected to have a parallel or opposing action.
Description
Keywords
Serotonin, probabilistic reversal learning, tryptophan depletion, Feedback, Female, Humans, Male, Reversal Learning, Sample Size, Serotonin, Tryptophan
Journal Title
Journal of Psychopharmacology
Conference Name
Journal ISSN
0269-8811
1461-7285
1461-7285
Volume Title
34
Publisher
SAGE
Publisher DOI
Sponsorship
Medical Research Council (MC_PC_17213)
Wellcome Trust (104631/Z/14/Z)
Wellcome Trust (104631/Z/14/Z)