Changes in quality of life, health status and other patient-reported outcomes following simultaneous pancreas and kidney transplantation (SPKT): a quantitative and qualitative analysis within a UK-wide programme.
Watson, Christopher JE
Oniscu, Gabriel C
Tomson, Charles RV
Johnson, Rachel J
Bradley, J Andrew
Frontiers Media SA
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Gibbons, A., Cinnirella, M., Bayfield, J., Watson, C. J., Oniscu, G. C., Draper, H., Tomson, C. R., et al. (2020). Changes in quality of life, health status and other patient-reported outcomes following simultaneous pancreas and kidney transplantation (SPKT): a quantitative and qualitative analysis within a UK-wide programme.. Transpl Int, 33 (10), 1230-1243. https://doi.org/10.1111/tri.13677
We examined quality of life (QoL) and other patient-reported outcome measures (PROMs) in 95 simultaneous pancreas and kidney transplant (SPKT) recipients and 41 patients wait-listed for SPKT recruited to the UK Access to Transplantation and Transplant Outcome Measures (ATTOM) programme. Wait-listed patients transplanted within 12 months of recruitment (n = 22) were followed 12 months post-transplant and compared with those still wait-listed (n = 19) to examine pre- to post-transplant changes. Qualitative interviews with ten SPKT recipients 12 months post-transplant were analysed thematically. Cross-sectional analyses showed several better 12-month outcomes for SPKT recipients compared with those still wait-listed, a trend to better health utilities but no difference in diabetes-specific QoL or diabetes treatment satisfaction. Pre- to post-transplant, SPKT recipients showed improved treatment satisfaction, well-being, self-reported health, generic QoL and less negative impact on renal-specific QoL (ps < 0.05). Health utility values were better overall in transplant recipients and neither these nor diabetes-specific QoL changed significantly in either group. Pre-emptive transplant advantages seen in 12-month cross-sectional analyses disappeared when controlling for baseline values. Qualitative findings indicated diabetes complications, self-imposed blood glucose monitoring and dietary restrictions continued to impact QoL negatively post-transplant. Unrealistic expectations of SPKT caused some disappointment. Measuring condition-specific PROMs over time will help in demonstrating the benefits and limitations of SPKT.
Pancreas, Humans, Blood Glucose, Blood Glucose Self-Monitoring, Kidney Transplantation, Pancreas Transplantation, Cross-Sectional Studies, Health Status, Quality of Life, United Kingdom, Patient Reported Outcome Measures
External DOI: https://doi.org/10.1111/tri.13677
This record's URL: https://www.repository.cam.ac.uk/handle/1810/307770
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