IBD considerations in spondyloarthritis
Publication Date
2020-07-09Journal Title
Therapeutic Advances in Musculoskeletal Disease
Publisher
SAGE Publications
Volume
12
Language
en
Type
Article
This Version
VoR
Metadata
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Di Jiang, C., & Raine, T. (2020). IBD considerations in spondyloarthritis. Therapeutic Advances in Musculoskeletal Disease, 12 https://doi.org/10.1177/1759720x20939410
Abstract
Spondyloarthritis (SpA) may be regarded a family of auto-inflammatory conditions with inflammation focused on the joints. These form part of a wider family of immune-mediated inflammatory diseases, which include inflammatory bowel diseases (IBD). These conditions share common elements of pathophysiology and it is perhaps unsurprising, therefore, that individuals with SpA frequently manifest gastrointestinal inflammation, to which the physician managing the patient with SpA must be alert. In this article, we review the shared epidemiology and pathophysiology of these conditions, before discussing approaches to diagnosis and management of inflammatory gastrointestinal pathology in patients seen in rheumatology clinics. In particular, we discuss the difference between non-specific gastrointestinal inflammation commonly described in this patient group and the more specific diagnosis of Crohn’s disease or ulcerative colitis. We describe the appropriate diagnostic workup for patients suspected of having IBD. In addition, we discuss how a diagnosis of IBD can inform treatment selection, highlighting important differences in treatment choice, drug dosing, monitoring and drug safety for this particular comorbid patient population.
Keywords
Extra-articular manifestations and comorbidities in spondyloarthritis, crohn’s disease, inflammatory bowel disease, spondyloarthritis, ulcerative colitis
Identifiers
10.1177_1759720x20939410
External DOI: https://doi.org/10.1177/1759720x20939410
This record's URL: https://www.repository.cam.ac.uk/handle/1810/307834
Rights
Embargo: ends 2020-07-09
Licence:
https://creativecommons.org/licenses/by/4.0/