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dc.contributor.authorWang, Luen
dc.contributor.authorThompson, Emilyen
dc.contributor.authorBates, Lucyen
dc.contributor.authorPither, Thomas Len
dc.contributor.authorHosgood, Sarahen
dc.contributor.authorNicholson, Michaelen
dc.contributor.authorWatson, Christopheren
dc.contributor.authorWilson, Colinen
dc.contributor.authorFisher, Andrew Jen
dc.contributor.authorAli, Simien
dc.contributor.authorDark, John Hen
dc.date.accessioned2020-07-10T23:30:30Z
dc.date.available2020-07-10T23:30:30Z
dc.date.issued2020-09en
dc.identifier.issn2373-8731
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/307860
dc.description.abstractAmong seven transplanted kidneys out of the 11 kidneys that underwent NMP, FMN levels at 60 minutes of NMP were significantly higher in the allografts that developed delayed graft function and primary non-function (p=0.02). 15 livers from 23 circulatory death donors that underwent NRP were deemed suitable for transplantation. Their FMN levels at 30 minutes of NRP were significantly lower than those not procured for transplantation (p=0.004). In contrast, little FMN was released during the 8 lung perfusions. Conclusions: This proof of concept study suggested that FMN in the perfusates of kidney NMP has the potential to predict post-transplant renal function, while FMN at 30 minutes of NRP predicts whether a liver would be accepted for transplantation. 5 More work is required to validate the role of FMN as a putative biomarker to facilitate safe and reliable decision making prior to embarking on transplantation.
dc.description.sponsorshipNIHR BTRU
dc.format.mediumElectronic-eCollectionen
dc.languageengen
dc.publisherWolters Kluwer
dc.rightsAll rights reserved
dc.rights.uri
dc.titleFlavin Mononucleotide as a Biomarker of Organ Quality-A Pilot Study.en
dc.typeArticle
prism.issueIdentifier9en
prism.publicationDate2020en
prism.publicationNameTransplantation directen
prism.startingPagee600
prism.volume6en
dc.identifier.doi10.17863/CAM.54954
dcterms.dateAccepted2020-07-09en
rioxxterms.versionofrecord10.1097/txd.0000000000001046en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-09en
dc.contributor.orcidHosgood, Sarah [0000-0002-8039-143X]
dc.contributor.orcidNicholson, Michael [0000-0001-7620-0664]
dc.contributor.orcidWatson, Christopher [0000-0002-0590-4901]
dc.identifier.eissn2373-8731
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NIHR BTRU-2014-10027)
cam.orpheus.counter10*
rioxxterms.freetoread.startdate2023-07-10


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