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Autophagy in Neuronal Development and Plasticity.

Accepted version
Peer-reviewed

Type

Article

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Authors

Rubinsztein, David C 

Abstract

Autophagy is a highly conserved intracellular clearance pathway in which cytoplasmic contents are trafficked to the lysosome for degradation. Within neurons, it helps to remove damaged organelles and misfolded or aggregated proteins and has therefore been the subject of intense research in relation to neurodegenerative disease. However, far less is understood about the role of autophagy in other aspects of neuronal physiology. Here we review the literature on the role of autophagy in maintaining neuronal stem cells and in neuronal plasticity in adult life and we discuss how these contribute to structural and functional deficits observed in a range of human disorders.

Description

Keywords

autophagy, memory, neurogenesis, neuronal stem cell (NSC), plasticity, psychiatric disease, Autophagy, Humans, Lysosomes, Neurodegenerative Diseases, Neuronal Plasticity, Neurons

Journal Title

Trends Neurosci

Conference Name

Journal ISSN

0166-2236
1878-108X

Volume Title

43

Publisher

Elsevier BV