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dc.contributor.authorRule, M
dc.contributor.authorLoback, Adrianna R
dc.contributor.authorRaman, Dhruva
dc.contributor.authorDriscoll, Laura N
dc.contributor.authorHarvey, Christopher D
dc.contributor.authorO'Leary, Timothy
dc.date.accessioned2020-07-16T00:42:26Z
dc.date.available2020-07-16T00:42:26Z
dc.date.issued2020-07-14
dc.identifier.issn2050-084X
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/308004
dc.description.abstract<jats:p>Over days and weeks, neural activity representing an animal's position and movement in sensorimotor cortex has been found to continually reconfigure or 'drift' during repeated trials of learned tasks, with no obvious change in behavior. This challenges classical theories which assume stable engrams underlie stable behavior. However, it is not known whether this drift occurs systematically, allowing downstream circuits to extract consistent information. Analyzing long-term calcium imaging recordings from posterior parietal cortex in mice (Mus musculus), we show that drift is systematically constrained far above chance, facilitating a linear weighted readout of behavioural variables. However, a significant component of drift continually degrades a fixed readout, implying that drift is not confined to a null coding space. We calculate the amount of plasticity required to compensate drift independently of any learning rule, and find that this is within physiologically achievable bounds. We demonstrate that a simple, biologically plausible local learning rule can achieve these bounds, accurately decoding behavior over many days.</jats:p>
dc.languageen
dc.publishereLife Sciences Publications, Ltd
dc.rightsAll rights reserved
dc.titleStable task information from an unstable neural population
dc.typeArticle
prism.publicationNameeLife
prism.volume9
dc.identifier.doi10.17863/CAM.55100
dcterms.dateAccepted2020-06-17
rioxxterms.versionofrecord10.7554/elife.51121
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-06-17
dc.contributor.orcidRule, M [0000-0002-4196-774X]
dc.contributor.orcidRaman, Dhruva [0000-0002-8992-1353]
dc.contributor.orcidO'Leary, Timothy [0000-0002-1029-0158]
dc.identifier.eissn2050-084X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idEuropean Research Council (716643)
pubs.funder-project-idHuman Frontier Science Program (HFSP) (RGY0069/2017)
cam.issuedOnline2020-07-14


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