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dc.contributor.authorStrain, Tessa
dc.contributor.authorWijndaele, Katrien
dc.contributor.authorDempsey, Paddy C
dc.contributor.authorSharp, Stephen
dc.contributor.authorPearce, Matthew
dc.contributor.authorJeon, Justin
dc.contributor.authorLindsay, Timothy
dc.contributor.authorWareham, Nicholas
dc.contributor.authorBrage, Soren
dc.date.accessioned2020-07-16T23:30:28Z
dc.date.available2020-07-16T23:30:28Z
dc.date.issued2020-09
dc.identifier.issn1078-8956
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/308030
dc.description.abstractUse of wearable devices that monitor physical activity is projected to increase more than fivefold per half-decade1. We investigated how device-based physical activity energy expenditure (PAEE) and different intensity profiles were associated with all-cause mortality. We used a network harmonization approach to map dominant-wrist acceleration to PAEE in 96,476 UK Biobank participants (mean age 62 years, 56% female). We also calculated the fraction of PAEE accumulated from moderate-to-vigorous-intensity physical activity (MVPA). Over the median 3.1-year follow-up period (302,526 person-years), 732 deaths were recorded. Higher PAEE was associated with a lower hazard of all-cause mortality for a constant fraction of MVPA (for example, 21% (95% confidence interval 4-35%) lower hazard for 20 versus 15 kJ kg-1 d-1 PAEE with 10% from MVPA). Similarly, a higher MVPA fraction was associated with a lower hazard when PAEE remained constant (for example, 30% (8-47%) lower hazard when 20% versus 10% of a fixed 15 kJ kg-1 d-1 PAEE volume was from MVPA). Our results show that higher volumes of PAEE are associated with reduced mortality rates, and achieving the same volume through higher-intensity activity is associated with greater reductions than through lower-intensity activity. The linkage of device-measured activity to energy expenditure creates a framework for using wearables for personalized prevention.
dc.description.sponsorshipTS, KW, SB, SJS, TL, PCD, MP, JJ and NJW are supported by the UK Medical Research Council (unit programme numbers MC_UU_12015/1 and MC_UU_12015/3). PCD is supported by a National Health and Medical Research Council of Australia research fellowship (#1142685). TL is supported by Cambridge Trust and St Catharine’s College.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll rights reserved
dc.subjectHumans
dc.subjectMonitoring, Physiologic
dc.subjectExercise
dc.subjectMortality
dc.subjectEnergy Metabolism
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectAccelerometry
dc.subjectWearable Electronic Devices
dc.titleWearable-device-measured physical activity and future health risk.
dc.typeArticle
prism.endingPage1391
prism.issueIdentifier9
prism.publicationDate2020
prism.publicationNameNat Med
prism.startingPage1385
prism.volume26
dc.identifier.doi10.17863/CAM.55125
dcterms.dateAccepted2020-07-07
rioxxterms.versionofrecord10.1038/s41591-020-1012-3
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-09
dc.contributor.orcidStrain, Tessa [0000-0002-7086-1047]
dc.contributor.orcidWijndaele, Katrien [0000-0003-2199-7981]
dc.contributor.orcidDempsey, Paddy C [0000-0002-1714-6087]
dc.contributor.orcidSharp, Stephen [0000-0003-2375-1440]
dc.contributor.orcidPearce, Matthew [0000-0003-3718-7502]
dc.contributor.orcidLindsay, Timothy [0000-0003-2857-1764]
dc.contributor.orcidWareham, Nicholas [0000-0003-1422-2993]
dc.contributor.orcidBrage, Soren [0000-0002-1265-7355]
dc.identifier.eissn1546-170X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MC_UU_12015/3)
pubs.funder-project-idMedical Research Council (MC_UU_12015/1)
pubs.funder-project-idMRC (MC_UU_00006/4)
pubs.funder-project-idDepartment of Health (via National Institute for Health Research (NIHR)) (NF-SI-0617-10149)
pubs.funder-project-idMRC (MC_UU_00006/1)
cam.issuedOnline2020-08-17
cam.orpheus.successMon Aug 24 14:55:59 BST 2020 - Embargo updated
cam.orpheus.counter5
rioxxterms.freetoread.startdate2021-02-17


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