The origins and genomic diversity of American Civil War Era smallpox vaccine strains
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Porter, Ashleigh F.
Dhody, Anna N.
Smith, Geoffrey L.
McCollum, Andrea M.
Davidson, Whitni B.
Raphenya, Amogelang R.
Lau, Tammy T. Y.
McArthur, Andrew G.
Golding, G. Brian
Holmes, Edward C.
Poinar, Hendrik N.
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Duggan, A. T., Klunk, J., Porter, A. F., Dhody, A. N., Hicks, R., Smith, G. L., Humphreys, M., et al. (2020). The origins and genomic diversity of American Civil War Era smallpox vaccine strains. [Other]. https://doi.org/10.1186/s13059-020-02079-z
Abstract: Vaccination has transformed public health, most notably including the eradication of smallpox. Despite its profound historical importance, little is known of the origins and diversity of the viruses used in smallpox vaccination. Prior to the twentieth century, the method, source and origin of smallpox vaccinations remained unstandardised and opaque. We reconstruct and analyse viral vaccine genomes associated with smallpox vaccination from historical artefacts. Significantly, we recover viral molecules through non-destructive sampling of historical materials lacking signs of biological residues. We use the authenticated ancient genomes to reveal the evolutionary relationships of smallpox vaccination viruses within the poxviruses as a whole.
Short Report, Vaccination, Smallpox, Vaccinia virus, Ancient DNA
Social Sciences and Humanities Research Council of Canada (430-2018-00662, Unknown)
Ontario Genomics Institute (OGI-170)
Natural Sciences and Engineering Research Council of Canada (RGPIN-2015-04477)
Australian Research Council (Unknown)
Wellcome Trust (Unknown)
Canadian Institutes of Health Research (PJT-156214)
Canadian Foundation for Innovation (Unknown)
Genome Canada (Unknown)
Red Wilson (Unknown)
External DOI: https://doi.org/10.1186/s13059-020-02079-z
This record's DOI: https://doi.org/10.17863/CAM.55237