Repository logo
 

Understanding HCMV Latency Using Unbiased Proteomic Analyses

Published version
Peer-reviewed

Change log

Authors

Poole, Emma 
Sinclair, John 

Abstract

Human cytomegalovirus (HCMV) establishes either a latent (non-productive) or lytic (productive) infection depending upon cell type, cytokine milieu and the differentiation status of the infected cell. Undifferentiated cells, such as precursor cells of the myeloid lineage, support a latent infection whereas terminally differentiated cells, such as monocytes or dendritic cells are an environment conducive to reactivation and support a lytic infection. The mechanisms which regulate HCMV in either a latent or lytic infection have been the focus of intense investigation with a view to developing novel treatments for HCMV-associated disease which can have a heavy clinical burden after reactivation or primary infection in, especially, the immune compromised. To this end, a number of studies have been carried out in an unbiased manner to address global changes occurring within the latently infected cell to address the molecular changes associated with HCMV latency. In this review, we will concentrate on the proteomic analyses which have been carried out in undifferentiated myeloid cells which either stably express specific viral latency associated genes in isolation or on cells which have been latently infected with virus.

Description

Keywords

human cytomegalovirus, proteome, latency

Journal Title

Pathogens

Conference Name

Journal ISSN

2076-0817

Volume Title

9

Publisher

MDPI
Sponsorship
Medical Research Council (MR/S00081X/1)