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The implementation of pharmacogenomics into UK General Practice: a qualitative study exploring barriers, challenges and opportunities

Published version
Peer-reviewed

Type

Article

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Authors

Abstract

Background Pharmacogenomics describes inter-patient genetic variability in drug responses. Information based on whole genome sequencing will soon open up the field of pharmacogenomics, and facilitate the use of genomic information relating to drug metabolism and drug responses. We undertook a qualitative study, aiming to explore the potential barriers, opportunities and challenges facing the implementation of pharmacogenomics into primary care. Methods Semi-structured interviews were undertaken with 18 clinical participants (16 GPs and 2 other clinicians). All interviews were recorded and transcribed verbatim. Using a thematic analysis approach, data items were coded, ordered and themes constructed. Results Most participants were aged 55-60 years and worked as part-time clinical GPs with other clearly defined roles. The emerging themes covered several areas of concern, including: the utility of pharmacogenomics and the value of introducing such testing into primary care; how to educate the primary care workforce and ‘mainstream’ pharmacogenomics; the ethical, legal and social aspects of pharmacogenomics and its impact on patients; and potential impacts on the healthcare system particularly around economics and informatics.

Description

Keywords

31 Biological Sciences, 3105 Genetics, Health Services, Human Genome, Clinical Research, Genetics, Patient Safety, 8 Health and social care services research, 8.1 Organisation and delivery of services, 3 Good Health and Well Being

Journal Title

Journal of Community Genetics

Conference Name

Journal ISSN

1868-310X
1868-6001

Volume Title

11

Publisher

Springer Nature
Sponsorship
none
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