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dc.contributor.authorFerreira, Isabella A. T. M.
dc.contributor.authorPorterfield, J. Zachary
dc.contributor.authorGupta, Ravindra K.
dc.contributor.authorMlcochova, Petra
dc.date.accessioned2020-08-02T01:12:10Z
dc.date.available2020-08-02T01:12:10Z
dc.date.issued2020-07-31
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/308678
dc.description.abstractMacrophages are the first line of defence against invading pathogens. They play a crucial role in immunity but also in regeneration and homeostasis. Their remarkable plasticity in their phenotypes and function provides them with the ability to quickly respond to environmental changes and infection. Recent work shows that macrophages undergo cell cycle transition from a G0/terminally differentiated state to a G1 state. This G0-to-G1 transition presents a window of opportunity for HIV-1 infection. Macrophages are an important target for HIV-1 but express high levels of the deoxynucleotide-triphosphate hydrolase SAMHD1, which restricts viral DNA synthesis by decreasing levels of dNTPs. While the G0 state is non-permissive to HIV-1 infection, a G1 state is very permissive to HIV-1 infection. This is because macrophages in a G1 state switch off the antiviral restriction factor SAMHD1 by phosphorylation, thereby allowing productive HIV-1 infection. Here, we explore the macrophage cell cycle and the interplay between its regulation and permissivity to HIV-1 infection.
dc.languageen
dc.publisherMDPI
dc.subjectHIV
dc.subjectSAMHD1
dc.subjectmacrophage
dc.subjectcell cycle
dc.subjectcell arrest
dc.subjectG0/G1 phase
dc.titleCell Cycle Regulation in Macrophages and Susceptibility to HIV-1
dc.typeArticle
dc.date.updated2020-08-02T01:12:09Z
prism.issueIdentifier8
prism.publicationNameViruses
prism.volume12
dc.identifier.doi10.17863/CAM.55766
dcterms.dateAccepted2020-07-28
rioxxterms.versionofrecord10.3390/v12080839
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidMlcochova, Petra [0000-0001-6908-9363]
dc.identifier.eissn1999-4915


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