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dc.contributor.authorZeberg, Hugoen
dc.contributor.authorDannemann, Michaelen
dc.contributor.authorSahlholm, Kristofferen
dc.contributor.authorTsuo, Kristinen
dc.contributor.authorMaricic, Tomislaven
dc.contributor.authorWiebe, Victoren
dc.contributor.authorHevers, Wulfen
dc.contributor.authorRobinson, Hughen
dc.contributor.authorKelso, Janeten
dc.contributor.authorPääbo, Svanteen
dc.date.accessioned2020-08-03T23:30:54Z
dc.date.available2020-08-03T23:30:54Z
dc.date.issued2020-07-15en
dc.identifier.issn0960-9822
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/308712
dc.description.abstractThe sodium channel Nav1.7 is crucial for impulse generation and conduction in peripheral pain pathways [1]. In Neanderthals, the Nav1.7 protein carried three amino acid substitutions (M932L, V991L, and D1908G) relative to modern humans. We expressed Nav1.7 proteins carrying all combinations of these substitutions and studied their electrophysiological effects. Whereas the single amino acid substitutions do not affect the function of the ion channel, the full Neanderthal variant carrying all three substitutions, as well as the combination of V991L with D1908G, shows reduced inactivation, suggesting that peripheral nerves were more sensitive to painful stimuli in Neanderthals than in modern humans. We show that, due to gene flow from Neanderthals, the three Neanderthal substitutions are found in ∼0.4% of present-day Britons, where they are associated with heightened pain sensitivity.
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectNeanderthalsen
dc.subjectgene flowen
dc.subjectintrogressionen
dc.subjectpainen
dc.subjectsodium channelen
dc.titleA Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans.en
dc.typeArticle
prism.publicationDate2020en
prism.publicationNameCurrent Biologyen
dc.identifier.doi10.17863/CAM.55801
dcterms.dateAccepted2020-06-12en
rioxxterms.versionofrecord10.1016/j.cub.2020.06.045en
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-07-15en
dc.contributor.orcidRobinson, Hugh [0000-0002-5048-9954]
dc.identifier.eissn1879-0445
rioxxterms.typeJournal Article/Reviewen


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Attribution 4.0 International
Except where otherwise noted, this item's licence is described as Attribution 4.0 International