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dc.contributor.authorChristie, Graham
dc.contributor.authorSetlow, Peter
dc.date.accessioned2020-08-03T23:31:34Z
dc.date.available2020-08-03T23:31:34Z
dc.date.issued2020-10
dc.identifier.issn0898-6568
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/308735
dc.description.abstractHow might a microbial cell that is entirely metabolically dormant - and which has the ability to remain so for extended periods of time - irreversibly commit itself to resuming vegetative growth within seconds of being exposed to certain amino acids or sugars? That this process takes place in the absence of any detectable ATP or de novo protein synthesis, and relies upon a pre-formed apparatus that is immobilised, respectively, in a semi-crystalline membrane or multi-layered proteinaceous coat, only exacerbates the challenge facing spores of Bacillales species when stimulated to germinate. Whereas the process by which spores are formed in response to nutrient starvation - sporulation - involves the orchestrated interplay between hundreds of distinct proteins, the process by which spores return to life - germination - is a much simpler affair, requiring a handful of receptor and channel proteins complemented with specialized peptidoglycan lysins. Despite this relative simplicity, and research effort spanning many decades, comprehensive understanding of key molecular and biochemical details and, in particular signal transduction mechanisms associated with spore germination, has remained elusive. In this review we provide an up to date overview of the field while identifying what we consider to be the key gaps in knowledge associated with germination of Bacillales spores, suggesting also technical approaches that may provide fresh insight to this unique biological process.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherElsevier BV
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.titleBacillus spore germination: Knowns, unknowns and what we need to learn.
dc.typeArticle
prism.publicationDate2020
prism.publicationNameCell Signal
prism.startingPage109729
prism.volume74
dc.identifier.doi10.17863/CAM.55824
dcterms.dateAccepted2020-07-21
rioxxterms.versionofrecord10.1016/j.cellsig.2020.109729
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-10
dc.contributor.orcidChristie, Graham [0000-0001-7177-9646]
dc.identifier.eissn1873-3913
rioxxterms.typeJournal Article/Review
cam.issuedOnline2020-07-25
cam.orpheus.successMon Aug 10 08:15:23 BST 2020 - Embargo updated
rioxxterms.freetoread.startdate2021-07-25


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International