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dc.contributor.authorPuaud, Mickaelen
dc.contributor.authorHiguera-Matas, Alejandroen
dc.contributor.authorBrunault, Paulen
dc.contributor.authorEveritt, Barryen
dc.contributor.authorBelin, Daviden
dc.date.accessioned2020-08-03T23:31:48Z
dc.date.available2020-08-03T23:31:48Z
dc.date.issued2021-02en
dc.identifier.issn0006-3223
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/308743
dc.description.abstractBackground: Individuals addicted to cocaine spend much of their time foraging for the drug. Pavlovian drug-associated conditioned stimuli exert a major influence on the initiation and maintenance of drug seeking often long into abstinence, especially when presented response-contingently, acting as conditioned reinforcers that bridge delays to drug use. The acquisition of cue-controlled cocaine seeking has been shown to depend on functional interactions between the basolateral amygdala (BLA) and the core of the nucleus accumbens (NAcC). However, the precise neuronal circuits underlying the acquisition of cue-controlled cocaine seeking behaviour have not been elucidated. Methods: Here we used a projection-specific Cre-dependent DREADD-mediated causal approach to test the hypothesis that the direct projections from the BLA to the NAcC are required for the acquisition of cue-controlled cocaine seeking behaviour. Results: In Sprague Dawley rats with cre-mediated expression of the inhibitory DREADD hM4D(Gi) in the NAcC projecting BLA neurons, treatment with CNO, but not vehicle, selectively prevented the impact of cocaine-associated conditioned reinforcement on cocaine seeking under a second-order schedule of reinforcement. This effect was attributable to the chemogenetic inhibition of the NAcC projecting BLA neurons as it was reversible, and absent in CNO-treated rats expressing an empty control virus. In contrast, chemogenetic inhibition of the anterior insula, which receives collateral projections from NAcC projecting BLA neurons, was without effect. Conclusions: These data demonstrate that the acquisition of cue-controlled cocaine seeking that depends on the conditioned reinforcing effects of cocaine cues require activity in the direct projections from the basolateral amygdala to the NAcC.
dc.description.sponsorshipLeverhulme Trust
dc.format.mediumPrint-Electronicen
dc.languageengen
dc.publisherElsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectNucleus Accumbensen
dc.subjectAnimalsen
dc.subjectRatsen
dc.subjectRats, Sprague-Dawleyen
dc.subjectCocaineen
dc.subjectSelf Administrationen
dc.subjectCuesen
dc.subjectDrug-Seeking Behavioren
dc.subjectBasolateral Nuclear Complexen
dc.titleThe Basolateral Amygdala to Nucleus Accumbens Core Circuit Mediates the Conditioned Reinforcing Effects of Cocaine-Paired Cues on Cocaine Seeking.en
dc.typeArticle
prism.endingPage365
prism.issueIdentifier4en
prism.publicationDate2021en
prism.publicationNameBiological psychiatryen
prism.startingPage356
prism.volume89en
dc.identifier.doi10.17863/CAM.55832
dcterms.dateAccepted2020-07-27en
rioxxterms.versionofrecord10.1016/j.biopsych.2020.07.022en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2021-02en
dc.contributor.orcidPuaud, Mickael [0000-0002-7943-1801]
dc.contributor.orcidHiguera-Matas, Alejandro [0000-0003-3438-9387]
dc.contributor.orcidBrunault, Paul [0000-0001-9317-228X]
dc.contributor.orcidEveritt, Barry [0000-0003-4431-6536]
dc.contributor.orcidBelin, David [0000-0002-7383-372X]
dc.identifier.eissn1873-2402
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idLeverhulme Trust (RPG-2016-117)
pubs.funder-project-idMRC (MR/N02530X/1)
cam.orpheus.successWed Aug 19 08:05:13 BST 2020 - Embargo updated*
cam.orpheus.counter1*
rioxxterms.freetoread.startdate2021-08-31


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Attribution-NonCommercial-NoDerivatives 4.0 International
Except where otherwise noted, this item's licence is described as Attribution-NonCommercial-NoDerivatives 4.0 International