Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
Islam, Md. Taufiqul
Kim, Deok Ryun
Khan, Ashraful Islam
Bhattacharya, Sujit K.
Holt, Kathryn E.
Kim, Jerome H.
Clemens, John D.
PLOS Neglected Tropical Diseases
Public Library of Science
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Im, J., Islam, M. T., Kim, D. R., Ahmmed, F., Chon, Y., Zaman, K., Khan, A. I., et al. (2020). Protection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata. PLOS Neglected Tropical Diseases, 14 (8)https://doi.org/10.1371/journal.pntd.0008530
We evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysaccharide typhoid vaccine in Kolkata, India. A population of 70,566 individuals, of whom 37,673 were vaccinated with one dose of either Vi vaccine or a control (Hepatitis A) vaccine, were observed for four years. Surveillance detected 315 first typhoid visits, among whom 4 developed subsequent typhoid, 3 due to reinfection, defined using genomic criteria and corresponding to -124% (95% CI: -599, 28) protection by the initial illness. Point estimates of protection conferred by an initial illness were negative or negligible in both vaccinated and non-vaccinated subjects, though confidence intervals around the point estimates were wide. These data provide little support for a protective immunizing effect of clinically treated typhoid illness, though modest levels of protection cannot be excluded.
Research Article, Medicine and health sciences, Biology and life sciences
Bill and Melinda Gates Foundation (OPP1171432)
External DOI: https://doi.org/10.1371/journal.pntd.0008530
This record's URL: https://www.repository.cam.ac.uk/handle/1810/309307
Attribution 4.0 International (CC BY 4.0)
Licence URL: https://creativecommons.org/licenses/by/4.0/