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dc.contributor.authorIm, Justin
dc.contributor.authorIslam, Md. Taufiqul
dc.contributor.authorKim, Deok Ryun
dc.contributor.authorAhmmed, Faisal
dc.contributor.authorChon, Yun
dc.contributor.authorZaman, K.
dc.contributor.authorKhan, Ashraful Islam
dc.contributor.authorAli, Mohammad
dc.contributor.authorSur, Dipika
dc.contributor.authorKanungo, Suman
dc.contributor.authorDutta, Shanta
dc.contributor.authorBhattacharya, Sujit K.
dc.contributor.authorDougan, Gordon
dc.contributor.authorHolt, Kathryn E.
dc.contributor.authorMarks, Florian
dc.contributor.authorKim, Jerome H.
dc.contributor.authorQadri, Firdausi
dc.contributor.authorClemens, John D.
dc.date.accessioned2020-08-18T01:10:00Z
dc.date.available2020-08-18T01:10:00Z
dc.date.issued2020-08-17
dc.date.submitted2019-08-05
dc.identifier.otherpntd-d-19-01180
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/309307
dc.description.abstractWe evaluated the protection conferred by a first documented visit for clinical care of typhoid fever against recurrent typhoid fever prompting a visit. This study takes advantage of multi-year follow-up of a population with endemic typhoid participating in a cluster-randomized control trial of Vi capsular polysaccharide typhoid vaccine in Kolkata, India. A population of 70,566 individuals, of whom 37,673 were vaccinated with one dose of either Vi vaccine or a control (Hepatitis A) vaccine, were observed for four years. Surveillance detected 315 first typhoid visits, among whom 4 developed subsequent typhoid, 3 due to reinfection, defined using genomic criteria and corresponding to -124% (95% CI: -599, 28) protection by the initial illness. Point estimates of protection conferred by an initial illness were negative or negligible in both vaccinated and non-vaccinated subjects, though confidence intervals around the point estimates were wide. These data provide little support for a protective immunizing effect of clinically treated typhoid illness, though modest levels of protection cannot be excluded.
dc.languageen
dc.publisherPublic Library of Science
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectResearch Article
dc.subjectMedicine and health sciences
dc.subjectBiology and life sciences
dc.titleProtection conferred by typhoid fever against recurrent typhoid fever in urban Kolkata
dc.typeArticle
dc.date.updated2020-08-18T01:09:59Z
prism.issueIdentifier8
prism.publicationNamePLOS Neglected Tropical Diseases
prism.volume14
dc.identifier.doi10.17863/CAM.56405
dcterms.dateAccepted2020-06-27
rioxxterms.versionofrecord10.1371/journal.pntd.0008530
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisoreditor: Diemert, David Joseph
dc.contributor.orcidIm, Justin [0000-0002-3762-084X]
dc.identifier.eissn1935-2735
pubs.funder-project-idBill and Melinda Gates Foundation (OPP1171432)


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)