Show simple item record

dc.contributor.authorLumby, Casper K
dc.contributor.authorZhao, Lei
dc.contributor.authorBreuer, Judith
dc.contributor.authorIllingworth, Christopher JR
dc.date.accessioned2020-08-18T05:10:45Z
dc.date.available2020-08-18T05:10:45Z
dc.date.issued2020-08-10
dc.date.submitted2020-03-13
dc.identifier.other56915
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/309309
dc.descriptionFunder: Isaac Newton Trust; FundRef: http://dx.doi.org/10.13039/501100004815
dc.descriptionFunder: Helsingin Yliopisto; FundRef: http://dx.doi.org/10.13039/100007797
dc.description.abstractStrains of the influenza virus form coherent global populations, yet exist at the level of single infections in individual hosts. The relationship between these scales is a critical topic for understanding viral evolution. Here we investigate the within-host relationship between selection and the stochastic effects of genetic drift, estimating an effective population size of infection Ne for influenza infection. Examining whole-genome sequence data describing a chronic case of influenza B in a severely immunocompromised child we infer an Ne of 2.5 × 107 (95% confidence range 1.0 × 107 to 9.0 × 107) suggesting that genetic drift is of minimal importance during an established influenza infection. Our result, supported by data from influenza A infection, suggests that positive selection during within-host infection is primarily limited by the typically short period of infection. Atypically long infections may have a disproportionate influence upon global patterns of viral evolution.
dc.languageen
dc.publishereLife Sciences Publications, Ltd
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en
dc.subjectShort Report
dc.subjectEvolutionary Biology
dc.subjectMicrobiology and Infectious Disease
dc.subjectwithin-host evolution
dc.subjectgenetic drift
dc.subjecteffective population size
dc.subjectselection
dc.subjectVirus
dc.titleA large effective population size for established within-host influenza virus infection
dc.typeArticle
dc.date.updated2020-08-18T05:10:44Z
prism.publicationNameeLife
prism.volume9
dc.identifier.doi10.17863/CAM.56407
dcterms.dateAccepted2020-07-30
rioxxterms.versionofrecord10.7554/elife.56915
rioxxterms.versionVoR
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/
datacite.contributor.supervisorsenior_editor: Walczak, Aleksandra M
datacite.contributor.supervisoreditor: Nourmohammad, Armita
dc.contributor.orcidLumby, Casper K [0000-0001-8329-9228]
dc.contributor.orcidIllingworth, Christopher JR [0000-0002-0030-2784]
dc.identifier.eissn2050-084X
pubs.funder-project-idWellcome (101239/Z/13/Z)
pubs.funder-project-idWellcome (101239/Z/13/A)
pubs.funder-project-idWellcome (105365/Z/14/Z)


Files in this item

Thumbnail
Thumbnail
Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's licence is described as Attribution 4.0 International (CC BY 4.0)