Show simple item record

dc.contributor.authorPassos Bastos, Carlos
dc.contributor.authorThom, William D
dc.contributor.authorReilly, Beth
dc.contributor.authorBatalha, Iris L
dc.contributor.authorBurge Rogers, Maedee L
dc.contributor.authorMcCrone, Ian
dc.contributor.authorFaria, Nuno
dc.contributor.authorPowell, Jonathan
dc.date.accessioned2020-08-18T23:30:41Z
dc.date.available2020-08-18T23:30:41Z
dc.date.issued2020-09-15
dc.identifier.issn2045-2322
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/309349
dc.description.abstractBandaging is a steadfast but time-consuming component of wound care with limited technical advancements to date. Bandages must be changed and infection risk managed. Rapid-set liquid bandages are efficient alternatives but lack durability or inherent infection control. We show here that antibacterial zinc (Zn) and copper (Cu) species greatly enhance the barrier properties of the natural, waterproof, bio-adhesive polymer, shellac. The material demonstrated marked antibacterial contact properties and, in ex-vivo studies, effectively locked-in pre-applied therapeutics. When challenged in vivo with the polybacterial bovine wound infection 'digital dermatitis', Zn/Cu-shellac adhered rapidly and robustly over pre-applied antibiotic. The bandage self-degraded, appropriately, over 7 days despite extreme conditions (faecal slurry). Treatment was well-tolerated and clinical improvement was observed in animal mobility. This new class of bandage has promise for challenging topical situations in humans and other animals, especially away from controlled, sterile clinical settings where wounds urgently require protection from environmental and bacterial contamination.
dc.format.mediumElectronic
dc.languageeng
dc.publisherSpringer Science and Business Media LLC
dc.rightsAll rights reserved
dc.subjectAnimals
dc.subjectCattle
dc.subjectHumans
dc.subjectSurgical Wound Infection
dc.subjectCattle Diseases
dc.subjectCopper
dc.subjectZinc
dc.subjectAnti-Bacterial Agents
dc.subjectBandages
dc.subjectWound Healing
dc.subjectFemale
dc.titleRobust rapid-setting antibacterial liquid bandages.
dc.typeArticle
prism.issueIdentifier1
prism.publicationDate2020
prism.publicationNameSci Rep
prism.startingPage15067
prism.volume10
dc.identifier.doi10.17863/CAM.56441
dcterms.dateAccepted2020-08-12
rioxxterms.versionofrecord10.1038/s41598-020-71586-7
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2020-09-15
dc.contributor.orcidMcCrone, Ian [0000-0002-6437-2626]
dc.contributor.orcidPowell, Jonathan [0000-0003-2738-1715]
dc.identifier.eissn2045-2322
rioxxterms.typeJournal Article/Review
pubs.funder-project-idMedical Research Council (MR/R005699/1)
cam.issuedOnline2020-09-15
cam.orpheus.counter6
rioxxterms.freetoread.startdate2023-08-18


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record