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dc.contributor.authorBettinger, CJen
dc.contributor.authorEcker, Men
dc.contributor.authorYoshida Kozai, TDen
dc.contributor.authorMalliaras, Georgeen
dc.contributor.authorMeng, Een
dc.contributor.authorVoit, Wen
dc.date.accessioned2020-08-19T23:30:15Z
dc.date.available2020-08-19T23:30:15Z
dc.date.issued2020-08-01en
dc.identifier.issn0883-7694
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/309370
dc.description.abstractNeural interfaces serve as a cornerstone technology to better understand the nervous system and treat debilitating neurological disorders. The ideal implantable neural interface can be integrated with tissue using minimally invasive procedures and can record high fidelity neuronal activity for long periods in vivo. Chronically stable neural implants can serve as scientific tools and broaden the clinical and therapeutic impact of many neurotechnologies. However, formidable technical and design challenges remain. At present, many of these challenges are related to the materials, mechanics, and form factors of implantable neural interfaces. This perspective highlights recent progress and challenges related to arguably two of the most common failure modes for implantable neural interfaces: (1) compromised barrier layers and packaging leading to failure of electronic components; (2) encapsulation and rejection of the implant due to injurious tissue-biomaterials interactions, which erodes signal quality and bandwidth. Novel materials and device design concepts could address these failure modes thus improving the performance and translational prospects of neural interfaces. This perspectives article provides a brief overview of contemporary neural interfaces, highlights recent progress in chemistry, materials, and fabrication techniques to improve reliability of these implantable devices. Topics include novel barrier materials and harmonizing the various incongruences of the tissue-device interface. Challenges and opportunities related to the development and clinical translation of these devices will also be presented.
dc.publisherCambridge University Press (CUP)
dc.rightsAll rights reserved
dc.rights.uri
dc.titleRecent advances in neural interfaces - Materials chemistry to clinical translationen
dc.typeArticle
prism.endingPage668
prism.issueIdentifier8en
prism.publicationDate2020en
prism.publicationNameMRS Bulletinen
prism.startingPage655
prism.volume45en
dc.identifier.doi10.17863/CAM.56459
rioxxterms.versionofrecord10.1557/mrs.2020.195en
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden
rioxxterms.licenseref.startdate2020-08-01en
dc.contributor.orcidMalliaras, George [0000-0002-4582-8501]
dc.identifier.eissn1938-1425
rioxxterms.typeJournal Article/Reviewen
pubs.funder-project-idEuropean Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (732032)
pubs.funder-project-idKing Abdullah University of Science and Technology (KAUST) (OSR-2016-CRG5-3003.2)
cam.orpheus.successMon Aug 24 14:55:51 BST 2020 - Embargo updated*
rioxxterms.freetoread.startdate2021-02-01


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