Guidelines for performing Mendelian randomization investigations
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Authors
Davey Smith, George
Davies, Neil
Dudbridge, Frank
Gill, Dipender
Glymour, Maria
Hartwig, Fernando
Holmes, Michael
Minelli, Cosetta
Relton, Caroline
Theodoratou, Evropi
Journal Title
Wellcome Open Research
ISSN
2398-502X
Volume
4
Number
186
Language
English
Type
Article
This Version
VoR
Metadata
Show full item recordCitation
Burgess, S., Davey Smith, G., Davies, N., Dudbridge, F., Gill, D., Glymour, M., Hartwig, F., et al. (2020). Guidelines for performing Mendelian randomization investigations. Wellcome Open Research, 4 (186)https://doi.org/10.12688/wellcomeopenres.15555.2
Abstract
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
Identifiers
External DOI: https://doi.org/10.12688/wellcomeopenres.15555.2
This record's URL: https://www.repository.cam.ac.uk/handle/1810/309427