Guidelines for performing Mendelian randomization investigations
Published version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Burgess, Stephen https://orcid.org/0000-0001-5365-8760
Davey Smith, George
Davies, Neil
Dudbridge, Frank
Gill, Dipender
Abstract
This paper provides guidelines for performing Mendelian randomization investigations. It is aimed at practitioners seeking to undertake analyses and write up their findings, and at journal editors and reviewers seeking to assess Mendelian randomization manuscripts. The guidelines are divided into nine sections: motivation and scope, data sources, choice of genetic variants, variant harmonization, primary analysis, supplementary and sensitivity analyses (one section on robust methods and one on other approaches), data presentation, and interpretation. These guidelines will be updated based on feedback from the community and advances in the field. Updates will be made periodically as needed, and at least every 18 months.
Description
Keywords
Mendelian randomization, causal inference, genetic epidemiology, guidelines
Journal Title
Wellcome Open Research
Conference Name
Journal ISSN
2398-502X
2398-502X
2398-502X
Volume Title
4
Publisher
F1000 Research Ltd
Publisher DOI
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
Medical Research Council (MC_UU_00002/7)