In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.
dc.contributor.author | Malpetti, Maura | |
dc.contributor.author | Rittman, Timothy | |
dc.contributor.author | Jones, Simon | |
dc.contributor.author | Cope, Thomas | |
dc.contributor.author | Passamonti, Luca | |
dc.contributor.author | Bevan-Jones, William Richard | |
dc.contributor.author | Patterson, Karalyn | |
dc.contributor.author | Fryer, Timothy | |
dc.contributor.author | Hong, Young | |
dc.contributor.author | Aigbirhio, Franklin | |
dc.contributor.author | O'Brien, John | |
dc.contributor.author | Rowe, James | |
dc.date.accessioned | 2020-08-27T23:30:43Z | |
dc.date.available | 2020-08-27T23:30:43Z | |
dc.date.issued | 2021-03 | |
dc.identifier.issn | 0022-3050 | |
dc.identifier.uri | https://www.repository.cam.ac.uk/handle/1810/309716 | |
dc.description.abstract | INTRODUCTION: We report in vivo patterns of neuroinflammation and abnormal protein aggregation in seven cases of familial frontotemporal dementia (FTD) with mutations in MAPT, GRN and C9orf72 genes. METHODS: Using positron emission tomography (PET), we explored the association of the distribution of activated microglia, as measured by the radioligand [11C]PK11195, and the regional distribution of tau or TDP-43 pathology, indexed using the radioligand [18F]AV-1451. The familial FTD PET data were compared with healthy controls. RESULTS: Patients with familial FTD across all mutation groups showed increased [11C]PK11195 binding predominantly in frontotemporal regions, with additional regions showing abnormalities in individuals. Patients with MAPT mutations had a consistent distribution of [18F]AV-1451 binding across the brain, with heterogeneous distributions among carriers of GRN and C9orf72 mutations. DISCUSSION: This case series suggests that neuroinflammation is part of the pathophysiology of familial FTD, warranting further consideration of immunomodulatory therapies for disease modification and prevention. | |
dc.description.sponsorship | This study was co-funded by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre; the Wellcome Trust (103838); the Medical Research Council (MR/P01271X/1); a Cambridge Trust & Sidney Sussex College Scholarship; and the Cambridge Centre for Parkinson-Plus. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. | |
dc.format.medium | Print-Electronic | |
dc.language | eng | |
dc.publisher | BMJ | |
dc.rights | All rights reserved | |
dc.subject | Humans | |
dc.subject | tau Proteins | |
dc.subject | Positron-Emission Tomography | |
dc.subject | Aged | |
dc.subject | Middle Aged | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Frontotemporal Dementia | |
dc.subject | C9orf72 Protein | |
dc.subject | Progranulins | |
dc.title | In vivo PET imaging of neuroinflammation in familial frontotemporal dementia. | |
dc.type | Article | |
prism.endingPage | 322 | |
prism.issueIdentifier | 3 | |
prism.publicationDate | 2021 | |
prism.publicationName | J Neurol Neurosurg Psychiatry | |
prism.startingPage | 319 | |
prism.volume | 92 | |
dc.identifier.doi | 10.17863/CAM.56810 | |
dcterms.dateAccepted | 2020-08-25 | |
rioxxterms.versionofrecord | 10.1136/jnnp-2020-323698 | |
rioxxterms.version | AM | |
rioxxterms.licenseref.uri | http://www.rioxx.net/licenses/all-rights-reserved | |
rioxxterms.licenseref.startdate | 2021-03 | |
dc.contributor.orcid | Malpetti, Maura [0000-0001-8923-9656] | |
dc.contributor.orcid | Rittman, Timothy [0000-0003-1063-6937] | |
dc.contributor.orcid | Jones, Simon [0000-0001-9695-0702] | |
dc.contributor.orcid | Cope, Thomas [0000-0002-4751-1786] | |
dc.contributor.orcid | Passamonti, Luca [0000-0002-7937-0615] | |
dc.contributor.orcid | Patterson, Karalyn [0000-0003-1927-7424] | |
dc.contributor.orcid | Aigbirhio, Franklin [0000-0001-9453-5257] | |
dc.contributor.orcid | O'Brien, John [0000-0002-0837-5080] | |
dc.contributor.orcid | Rowe, James [0000-0001-7216-8679] | |
dc.identifier.eissn | 1468-330X | |
rioxxterms.type | Journal Article/Review | |
pubs.funder-project-id | Wellcome Trust (103838/Z/14/Z) | |
pubs.funder-project-id | Medical Research Council (MR/P01271X/1) | |
pubs.funder-project-id | Cambridge University Hospitals NHS Foundation Trust (CUH) (146281) | |
pubs.funder-project-id | Cambridge University Hospitals NHS Foundation Trust (CUH) (unknown) | |
pubs.funder-project-id | Medical Research Council (MR/M009041/1) | |
pubs.funder-project-id | Medical Research Council (MR/M024873/1) | |
pubs.funder-project-id | Medical Research Council (MR/K02308X/1) | |
cam.issuedOnline | 2020-10-29 | |
cam.orpheus.success | Mon Nov 02 07:31:07 GMT 2020 - Embargo updated | |
cam.orpheus.counter | 9 | |
rioxxterms.freetoread.startdate | 2020-10-29 |
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