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dc.contributor.authorMalpetti, Maura
dc.contributor.authorRittman, Timothy
dc.contributor.authorJones, Simon
dc.contributor.authorCope, Thomas
dc.contributor.authorPassamonti, Luca
dc.contributor.authorBevan-Jones, William Richard
dc.contributor.authorPatterson, Karalyn
dc.contributor.authorFryer, Timothy
dc.contributor.authorHong, Young
dc.contributor.authorAigbirhio, Franklin
dc.contributor.authorO'Brien, John
dc.contributor.authorRowe, James
dc.date.accessioned2020-08-27T23:30:43Z
dc.date.available2020-08-27T23:30:43Z
dc.date.issued2021-03
dc.identifier.issn0022-3050
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/309716
dc.description.abstractINTRODUCTION: We report in vivo patterns of neuroinflammation and abnormal protein aggregation in seven cases of familial frontotemporal dementia (FTD) with mutations in MAPT, GRN and C9orf72 genes. METHODS: Using positron emission tomography (PET), we explored the association of the distribution of activated microglia, as measured by the radioligand [11C]PK11195, and the regional distribution of tau or TDP-43 pathology, indexed using the radioligand [18F]AV-1451. The familial FTD PET data were compared with healthy controls. RESULTS: Patients with familial FTD across all mutation groups showed increased [11C]PK11195 binding predominantly in frontotemporal regions, with additional regions showing abnormalities in individuals. Patients with MAPT mutations had a consistent distribution of [18F]AV-1451 binding across the brain, with heterogeneous distributions among carriers of GRN and C9orf72 mutations. DISCUSSION: This case series suggests that neuroinflammation is part of the pathophysiology of familial FTD, warranting further consideration of immunomodulatory therapies for disease modification and prevention.
dc.description.sponsorshipThis study was co-funded by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre; the Wellcome Trust (103838); the Medical Research Council (MR/P01271X/1); a Cambridge Trust & Sidney Sussex College Scholarship; and the Cambridge Centre for Parkinson-Plus. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherBMJ
dc.rightsAll rights reserved
dc.subjectHumans
dc.subjecttau Proteins
dc.subjectPositron-Emission Tomography
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectFrontotemporal Dementia
dc.subjectC9orf72 Protein
dc.subjectProgranulins
dc.titleIn vivo PET imaging of neuroinflammation in familial frontotemporal dementia.
dc.typeArticle
prism.endingPage322
prism.issueIdentifier3
prism.publicationDate2021
prism.publicationNameJ Neurol Neurosurg Psychiatry
prism.startingPage319
prism.volume92
dc.identifier.doi10.17863/CAM.56810
dcterms.dateAccepted2020-08-25
rioxxterms.versionofrecord10.1136/jnnp-2020-323698
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-03
dc.contributor.orcidMalpetti, Maura [0000-0001-8923-9656]
dc.contributor.orcidRittman, Timothy [0000-0003-1063-6937]
dc.contributor.orcidJones, Simon [0000-0001-9695-0702]
dc.contributor.orcidCope, Thomas [0000-0002-4751-1786]
dc.contributor.orcidPassamonti, Luca [0000-0002-7937-0615]
dc.contributor.orcidPatterson, Karalyn [0000-0003-1927-7424]
dc.contributor.orcidAigbirhio, Franklin [0000-0001-9453-5257]
dc.contributor.orcidO'Brien, John [0000-0002-0837-5080]
dc.contributor.orcidRowe, James [0000-0001-7216-8679]
dc.identifier.eissn1468-330X
rioxxterms.typeJournal Article/Review
pubs.funder-project-idWellcome Trust (103838/Z/14/Z)
pubs.funder-project-idMedical Research Council (MR/P01271X/1)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (146281)
pubs.funder-project-idCambridge University Hospitals NHS Foundation Trust (CUH) (unknown)
pubs.funder-project-idMedical Research Council (MR/M009041/1)
pubs.funder-project-idMedical Research Council (MR/M024873/1)
cam.issuedOnline2020-10-29
cam.orpheus.successMon Nov 02 07:31:07 GMT 2020 - Embargo updated
cam.orpheus.counter9
rioxxterms.freetoread.startdate2020-10-29


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