Heritability of overlapping impulsivity and compulsivity dimensional phenotypes
Chamberlain, Samuel R.
Harrison, Ben J.
Youssef, George J.
Fontenelle, Leonardo F.
Nature Publishing Group UK
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Tiego, J., Chamberlain, S. R., Harrison, B. J., Dawson, A., Albertella, L., Youssef, G. J., Fontenelle, L. F., & et al. (2020). Heritability of overlapping impulsivity and compulsivity dimensional phenotypes. Scientific Reports, 10 (1)https://doi.org/10.1038/s41598-020-71013-x
Funder: David Winston Turner Endowment Fund
Abstract: Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive–compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A2 = 0.33), modest additive genetic or common environmental effects for obsessiveness (A2 = 0.25; C2 = 0.23), and moderate effects of common environment (C2 = 0.36) for the general dimension, This general impulsive–compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors.
Article, /631/477, /631/477/2811, article
National Health and Medical Research Council (1002458, APP1117188)
Wellcome Trust (110049/Z/15/Z)
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (E-26/103.252/2011)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (E-26/308237/2014-5)
External DOI: https://doi.org/10.1038/s41598-020-71013-x
This record's URL: https://www.repository.cam.ac.uk/handle/1810/309788