In this panel, we aim to explore what triggers social-environmental struggles to be turned into pathways to radically different futures, instead of feeding into the growing right-wing global tide. To address this aim we ask two specific research questions: Firstly, how do social-environmental struggles and movements relate to radical alternatives, socio-spatial transformations and grassroots innovations? Secondly, what structural factors and local specificities contribute to the development, endurance, up-scaling, dissolution or cooption of such radical alternatives and innovations, in specific global-local constellations? Our aim is to explore and compare the spatialities of resistance and transformative change in both urban and rural settings, across the Global South and North. We focus on cases where radical grassroots social innovations – defined as sets of social relations and practices that are initiated by networks of people which are autonomous from state institutions and capital forces and aim to generate radical, democratic, bottom up, and novel socially-environmentally sustainable and futures-oriented solutions– are a key aspect of community activism. By uncovering broader patterns of resources, possibilities, limitations, narrative frames, spatial practices and pathways of up-scaling such practices and relations in different contexts, we hope to reveal the connections between social struggles (collective action, with specific spatial narratives and practices), emerging radical alternatives, transformations and grassroots innovations (exceeding the limits of the local, at least in their imaginaries) and broader structural factors, thus making an important contribution in debates over radical alternatives to the neoliberal agenda.