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European polygenic risk score for prediction of breast cancer shows similar performance in Asian women.

Published version
Peer-reviewed

Type

Article

Change log

Authors

Mavaddat, Nasim 
Tai, Mei-Chee 
Mariapun, Shivaani 

Abstract

Polygenic risk scores (PRS) have been shown to predict breast cancer risk in European women, but their utility in Asian women is unclear. Here we evaluate the best performing PRSs for European-ancestry women using data from 17,262 breast cancer cases and 17,695 controls of Asian ancestry from 13 case-control studies, and 10,255 Chinese women from a prospective cohort (413 incident breast cancers). Compared to women in the middle quintile of the risk distribution, women in the highest 1% of PRS distribution have a ~2.7-fold risk and women in the lowest 1% of PRS distribution has ~0.4-fold risk of developing breast cancer. There is no evidence of heterogeneity in PRS performance in Chinese, Malay and Indian women. A PRS developed for European-ancestry women is also predictive of breast cancer risk in Asian women and can help in developing risk-stratified screening programmes in Asia.

Description

Keywords

Adult, Aged, Asia, Breast Neoplasms, Case-Control Studies, Europe, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Middle Aged, Multifactorial Inheritance, Odds Ratio, Polymorphism, Single Nucleotide, Prognosis, Risk

Journal Title

Nat Commun

Conference Name

Journal ISSN

2041-1723
2041-1723

Volume Title

11

Publisher

Springer Science and Business Media LLC
Sponsorship
Wellcome Trust (203477/Z/16/Z)
Cancer Research UK (20861)
Wellcome Trust (203477/B/16/Z)
National Cancer Institute (U19CA148065)
Medical Research Council (MR/P012930/1)
Cancer Research UK (A16563)
Cancer Research UK (A10118)
Cancer Research Uk (None)
National Institutes of Health (NIH) (via University of Southern California) (1 U19 CA148537-01)
Canadian Institutes of Health Research (CIHR) (via Universit� Laval) (unknown)
European Commission Horizon 2020 (H2020) Societal Challenges (634935)
European Commission (223175)
European Commission Horizon 2020 (H2020) Societal Challenges (633784)