The transferability of lipid loci across African, Asian and European cohorts
Millwood, Iona Y.
Nature Publishing Group UK
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Kuchenbaecker, K., Telkar, N., Reiker, T., Walters, R. G., Lin, K., Eriksson, A., Gurdasani, D., et al. (2019). The transferability of lipid loci across African, Asian and European cohorts. Nature Communications, 10 (1)https://doi.org/10.1038/s41467-019-12026-7
Abstract: Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23–0.28, p < 1.9 × 10−14). Overall, there is evidence of reproducibility for ~75% of the major lipid loci from European discovery studies, except triglyceride loci in the Ugandan samples (10% of loci). Individual transferable loci are identified using trans-ethnic colocalization. Ten of fourteen loci not transferable to the Ugandan population have pleiotropic associations with BMI in Europeans; none of the transferable loci do. The non-transferable loci might affect lipids by modifying food intake in environments rich in certain nutrients, which suggests a potential role for gene-environment interactions.
Article, /631/208/205/2138, /631/208/729, /631/208/457, /692/4019/592/2727, /45, /45/43, article
External DOI: https://doi.org/10.1038/s41467-019-12026-7
This record's URL: https://www.repository.cam.ac.uk/handle/1810/310620