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dc.contributor.authorKuchenbaecker, Karoline
dc.contributor.authorTelkar, Nikita
dc.contributor.authorReiker, Theresa
dc.contributor.authorWalters, Robin G.
dc.contributor.authorLin, Kuang
dc.contributor.authorEriksson, Anders
dc.contributor.authorGurdasani, Deepti
dc.contributor.authorGilly, Arthur
dc.contributor.authorSoutham, Lorraine
dc.contributor.authorTsafantakis, Emmanouil
dc.contributor.authorKaraleftheri, Maria
dc.contributor.authorSeeley, Janet
dc.contributor.authorKamali, Anatoli
dc.contributor.authorAsiki, Gershim
dc.contributor.authorMillwood, Iona Y.
dc.contributor.authorHolmes, Michael
dc.contributor.authorDu, Huaidong
dc.contributor.authorGuo, Yu
dc.contributor.authorKumari, Meena
dc.contributor.authorDedoussis, George
dc.contributor.authorLi, Liming
dc.contributor.authorChen, Zhengming
dc.contributor.authorSandhu, Manjinder S.
dc.contributor.authorZeggini, Eleftheria
dc.contributor.author
dc.contributor.authorBenzeval, Michaela
dc.contributor.authorBurton, Jonathan
dc.contributor.authorBuck, Nicholas
dc.contributor.authorJäckle, Annette
dc.contributor.authorLaurie, Heather
dc.contributor.authorLynn, Peter
dc.contributor.authorPudney, Stephen
dc.contributor.authorRabe, Birgitta
dc.contributor.authorWolke, Dieter
dc.date.accessioned2020-09-23T15:07:56Z
dc.date.available2020-09-23T15:07:56Z
dc.date.issued2019-09-24
dc.date.submitted2019-03-26
dc.identifier.others41467-019-12026-7
dc.identifier.other12026
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/310620
dc.description.abstractAbstract: Most genome-wide association studies are based on samples of European descent. We assess whether the genetic determinants of blood lipids, a major cardiovascular risk factor, are shared across populations. Genetic correlations for lipids between European-ancestry and Asian cohorts are not significantly different from 1. A genetic risk score based on LDL-cholesterol-associated loci has consistent effects on serum levels in samples from the UK, Uganda and Greece (r = 0.23–0.28, p < 1.9 × 10−14). Overall, there is evidence of reproducibility for ~75% of the major lipid loci from European discovery studies, except triglyceride loci in the Ugandan samples (10% of loci). Individual transferable loci are identified using trans-ethnic colocalization. Ten of fourteen loci not transferable to the Ugandan population have pleiotropic associations with BMI in Europeans; none of the transferable loci do. The non-transferable loci might affect lipids by modifying food intake in environments rich in certain nutrients, which suggests a potential role for gene-environment interactions.
dc.languageen
dc.publisherNature Publishing Group UK
dc.subjectArticle
dc.subject/631/208/205/2138
dc.subject/631/208/729
dc.subject/631/208/457
dc.subject/692/4019/592/2727
dc.subject/45
dc.subject/45/43
dc.subjectarticle
dc.titleThe transferability of lipid loci across African, Asian and European cohorts
dc.typeArticle
dc.date.updated2020-09-23T15:07:56Z
prism.issueIdentifier1
prism.publicationNameNature Communications
prism.volume10
dc.identifier.doi10.17863/CAM.57717
dcterms.dateAccepted2019-08-19
rioxxterms.versionofrecord10.1038/s41467-019-12026-7
rioxxterms.versionVoR
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/
dc.contributor.orcidKuchenbaecker, Karoline [0000-0001-9726-603X]
dc.contributor.orcidWalters, Robin G. [0000-0002-9179-0321]
dc.contributor.orcidGurdasani, Deepti [0000-0001-9996-6929]
dc.contributor.orcidSoutham, Lorraine [0000-0002-7546-9650]
dc.contributor.orcidSeeley, Janet [0000-0002-0583-5272]
dc.contributor.orcidSandhu, Manjinder S. [0000-0002-2725-142X]
dc.identifier.eissn2041-1723


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