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dc.contributor.authorOng, Jue-Sheng
dc.contributor.authorDerks, Eske M
dc.contributor.authorEriksson, Mikael
dc.contributor.authorAn, Jiyuan
dc.contributor.authorHwang, Liang-Dar
dc.contributor.authorEaston, Douglas
dc.contributor.authorPharoah, Paul
dc.contributor.authorBerchuck, Andrew
dc.contributor.authorKelemen, Linda E
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorHall, Per
dc.contributor.authorBojesen, Stig E
dc.contributor.authorWebb, Penelope M
dc.contributor.authorMacGregor, Stuart
dc.date.accessioned2020-09-23T23:30:54Z
dc.date.available2020-09-23T23:30:54Z
dc.date.issued2021-03-15
dc.identifier.issn0020-7136
dc.identifier.urihttps://www.repository.cam.ac.uk/handle/1810/310647
dc.description.abstractAlcohol consumption is correlated positively with risk for breast cancer in observational studies, but observational studies are subject to reverse causation and confounding. The association with epithelial ovarian cancer (EOC) is unclear. We performed both observational Cox regression and two-sample Mendelian randomization (MR) analyses using data from various European cohort studies (observational) and publicly available cancer consortia (MR). These estimates were compared to World Cancer Research Fund (WCRF) findings. In our observational analyses, the multivariable-adjusted hazard ratios (HR) for a one standard drink/day increase was 1.06 (95% confidence interval [CI]; 1.04, 1.08) for breast cancer and 1.00 (0.92, 1.08) for EOC, both of which were consistent with previous WCRF findings. MR ORs per genetically predicted one standard drink/day increase estimated via 34 SNPs using MR-PRESSO were 1.00 (0.93, 1.08) for breast cancer and 0.95 (0.85, 1.06) for EOC. Stratification by EOC subtype or estrogen receptor status in breast cancers made no meaningful difference to the results. For breast cancer, the CIs for the genetically derived estimates include the point-estimate from observational studies so are not inconsistent with a small increase in risk. Our data provide additional evidence that alcohol intake is unlikely to have anything other than a very small effect on risk of EOC.
dc.format.mediumPrint-Electronic
dc.languageeng
dc.publisherWiley
dc.rightsAll rights reserved
dc.subjectHumans
dc.subjectBreast Neoplasms
dc.subjectOvarian Neoplasms
dc.subjectOdds Ratio
dc.subjectCohort Studies
dc.subjectAlcohol Drinking
dc.subjectCausality
dc.subjectFemale
dc.subjectMendelian Randomization Analysis
dc.subjectCarcinoma, Ovarian Epithelial
dc.titleEvaluating the role of alcohol consumption in breast and ovarian cancer susceptibility using population-based cohort studies and two-sample Mendelian randomization analyses.
dc.typeArticle
prism.endingPage1350
prism.issueIdentifier6
prism.publicationDate2021
prism.publicationNameInt J Cancer
prism.startingPage1338
prism.volume148
dc.identifier.doi10.17863/CAM.57745
dcterms.dateAccepted2020-09-08
rioxxterms.versionofrecord10.1002/ijc.33308
rioxxterms.versionAM
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserved
rioxxterms.licenseref.startdate2021-03
dc.contributor.orcidOng, Jue-Sheng [0000-0002-6062-710X]
dc.contributor.orcidEaston, Douglas [0000-0003-2444-3247]
dc.contributor.orcidPharoah, Paul [0000-0001-8494-732X]
dc.contributor.orcidMatsuo, Keitaro [0000-0003-1761-6314]
dc.contributor.orcidBojesen, Stig E [0000-0002-4061-4133]
dc.identifier.eissn1097-0215
rioxxterms.typeJournal Article/Review
pubs.funder-project-idNational Cancer Institute (U19CA148065)
pubs.funder-project-idCancer Research UK (CRUK-A10710)
pubs.funder-project-idCancer Research UK (CRUK-A16563)
pubs.funder-project-idCancer Research UK (CRUK-A10118)
cam.issuedOnline2020-10-13
cam.orpheus.successMon Oct 12 07:30:37 BST 2020 - Embargo updated
cam.orpheus.counter1
rioxxterms.freetoread.startdate2021-09-25


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