Cardiometabolic Traits, Sepsis, and Severe COVID-19: A Mendelian Randomization Investigation.
Accepted version
Peer-reviewed
Repository URI
Repository DOI
Change log
Authors
Ponsford, Mark J
Gkatzionis, Apostolos
Walker, Venexia M
Grant, Andrew J
Wootton, Robyn E
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current coronavirus disease 2019 (COVID-19) pandemic. Many patients with severe COVID-19 develop sepsis. Cardiometabolic traits have been associated with increased risk of severe COVID-19 and sepsis, however it is difficult to infer causal effects from observational studies due to the possibility that any identified associations may be attributable to confounding.
Description
Keywords
Mendelian randomization analysis, coronavirus, risk factors, sepsis, Betacoronavirus, Body Mass Index, COVID-19, Case-Control Studies, Coronavirus Infections, Diabetes Mellitus, Type 2, Dyslipidemias, Gene-Environment Interaction, Genetic Association Studies, Genetic Predisposition to Disease, Host-Pathogen Interactions, Humans, Mendelian Randomization Analysis, Obesity, Pandemics, Phenotype, Pneumonia, Viral, Polymorphism, Single Nucleotide, Risk Factors, SARS-CoV-2, Sepsis, Severity of Illness Index, Smoking
Journal Title
Circulation
Conference Name
Journal ISSN
0009-7322
1524-4539
1524-4539
Volume Title
142
Publisher
Ovid Technologies (Wolters Kluwer Health)
Publisher DOI
Rights
All rights reserved
Sponsorship
Medical Research Council (MC_UU_00002/7)
Wellcome Trust (204623/Z/16/Z)
European Commission and European Federation of Pharmaceutical Industries and Associations (EFPIA) FP7 Innovative Medicines Initiative (IMI) (116074)
Wellcome Trust (204623/Z/16/Z)
European Commission and European Federation of Pharmaceutical Industries and Associations (EFPIA) FP7 Innovative Medicines Initiative (IMI) (116074)