Comparative mammary gland postnatal development and tumourigenesis in the sheep, cow, cat and rabbit: Exploring the menagerie.
Seminars in cell & developmental biology
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Hughes, K. (2021). Comparative mammary gland postnatal development and tumourigenesis in the sheep, cow, cat and rabbit: Exploring the menagerie.. Seminars in cell & developmental biology, 114 186-195. https://doi.org/10.1016/j.semcdb.2020.09.010
Sheep, cows, cats, and rabbits are kept by humans for agricultural purposes and as companion animals. Much of the mammary research in these species has focussed on mastitis in the case of ruminants and rabbits, and mammary tumourigenesis in cats and rabbits. However, similarities with the human breast suggest that these species may be currently underutilised as valuable comparative models of breast development and disease. The mammary gland undergoes cyclical postnatal development that will be considered here in the context of these non-traditional model species, with a focus on the mammary microenvironment at different postnatal developmental stages. The second part of this review will consider mammary tumour development. Ruminants are thought to be relatively ‘resistant’ to mammary tumourigenesis, likely due to multiple factors including functional properties of ruminant mammary stem/progenitor cells, diet, and/or the fact that production animals undergo a first parity soon after puberty. By contrast, unneutered female cats and rabbits have a propensity to develop mammary neoplasms, and subsets of these may constitute valuable comparative models of breast cancer.
Pathological Society of Great Britain and Ireland [grant number ICA 1019 02]; and the British Veterinary Association Animal Welfare Foundation Norman Hayward Fund [grant number NHF_2016_03_KH].
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External DOI: https://doi.org/10.1016/j.semcdb.2020.09.010
This record's URL: https://www.repository.cam.ac.uk/handle/1810/311043
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Licence URL: https://creativecommons.org/licenses/by-nc-nd/4.0/